ID   JJ012-TS4
AC   CVCL_D901
DR   BTO; BTO_0003043
DR   cancercelllines; CVCL_D901
DR   Wikidata; Q54898951
RX   PubMed=11796708;
RX   PubMed=14701864;
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Gly (c.394C>G); ClinVar=VCV000375892; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly199Val (c.596G>T); ClinVar=VCV000451799; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:220; ADAMTS4.
DI   NCIt; C7155; Primary central chondrosarcoma
DI   ORDO; Orphanet_55880; Chondrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D605 ! JJ012
SX   Male
AG   39Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 19
//
RX   PubMed=11796708; DOI=10.1074/jbc.M107443200;
RA   Gao G., Westling J., Thompson V.P., Howell T.D., Gottschall P.E.,
RA   Sandy J.D.;
RT   "Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by
RT   C-terminal truncation.";
RL   J. Biol. Chem. 277:11034-11041(2002).
//
RX   PubMed=14701864; DOI=10.1074/jbc.M312100200;
RA   Gao G., Plaas A., Thompson V.P., Jin S., Zuo F.-R., Sandy J.D.;
RT   "ADAMTS4 (aggrecanase-1) activation on the cell surface involves
RT   C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane
RT   type 4-matrix metalloproteinase and binding of the activated
RT   proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.";
RL   J. Biol. Chem. 279:10042-10051(2004).
//