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Cellosaurus JJ012 (CVCL_D605)

[Text version]
Cell line name JJ012
Synonyms JJO12; JJ
Accession CVCL_D605
Resource Identification Initiative To cite this cell line use: JJ012 (RRID:CVCL_D605)
Comments Doubling time: 0.9 day (PubMed=12168675).
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*44:02,44:02
HLA-CC*05:01,05:01
Disease Primary central chondrosarcoma (NCIt: C7155)
Chondrosarcoma (ORDO: Orphanet_55880)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D901 (JJ012-TS4)
Sex of cell Male
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792; PubMed=25877200

Markers:
AmelogeninX (PubMed=25877200)
X,Y (PubMed=19787792)
CSF1PO10
D2S133820,23
D3S135815,16,17,18 (PubMed=25877200)
16,17 (PubMed=19787792)
D5S81811,12
D7S8208,10
D8S117913
D13S31711
D16S53911,12
D18S5115 (PubMed=25877200)
15,17 (PubMed=19787792)
D19S43312,13
D21S1128,29
FGA21,22
Penta D11,13
Penta E7,15
SE3320.2,21
TH016,8
TPOX8,9
vWA15,16 (PubMed=25877200)
15,19 (PubMed=19787792)

Run an STR similarity search on this cell line
Publications

PubMed=8689637; DOI=10.1016/0304-3835(96)04274-7
Ashok A. Jagasia, Joel A. Block, Abid Qureshi, Manuel O. Diaz, Tsutomu Nobori, Steven Gitelis, Anand P. Iyer;
Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas.
Cancer Lett. 105:91-103(1996)

PubMed=10906887; DOI=10.1097/00003086-200007000-00038
Sean P. Scully, Keith R. Berend, Alison Toth, Wen-Ning Qi, Zhou Qi, Joel A. Block;
Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.
Clin. Orthop. Relat. Res. 376:291-303(2000)

PubMed=12168675; DOI=10.1016/S0736-0266(01)00172-3
Michelle Aileen Ghert, Wen-Ning Qi, Harold Paul Erickson, Joel A. Block, Sean P. Scully;
Tenascin-C expression and distribution in cultured human chondrocytes and chondrosarcoma cells.
J. Orthop. Res. 20:834-841(2002)

PubMed=12354749
James A. Martin, Erin Forest, Joel A. Block, Aloysius J. Klingelhutz, Brent Whited, Steven Gitelis, Andrew Wilkey, Joseph A. Buckwalter;
Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation.
Cell Growth Differ. 13:397-407(2002)

PubMed=19787792; DOI=10.1002/gcc.20717
Laura Ottaviano, Karl-Ludwig Schaefer, Melanie Gajewski, Wolfgang Huckenbeck, Stefan E. Baldus, Uwe Rogel, Carlos Mackintosh, Enrique de Alava, Ola Myklebost, Stine Henrichson Kresse, Leonardo Andres Meza-Zepeda ...Show all 18 authors... , Massimo Serra, Anne-Marie Cleton-Jansen, Pancras Cornelis Wilhelmus Hogendoorn, Horst Buerger, Thomas Aigner, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=22057234; DOI=10.1038/ng.1004; PMCID=PMC3427908
Twinkal Marfatia, Ronald van Eijk, Pio d'Adamo, Maayke A.J.H. van Ruler, Marieke Lydia Kuijjer, Jan Oosting, Anne-Marie Cleton-Jansen, Jolieke G. van Oosterwijk, Sofie L.J. Verbeke, Danielle Meijer, Tom van Wezel ...Show all 27 authors... , Karolin H. Nord, Luca Sangiorgi, Berkin Toker, Bernadette Liegl-Atzwanger, Mikel San-Julian, Raf Sciot, Nisha Limaye, Lars-Gunnar Kindblom, Soeren Daugaard, Catherine Godfraind, Laurence M. Boon, Miikka Vikkula, Kyle C. Kurek, Karoly Szuhai, Pim J. French, Judith V.M.G. Bovee; Show fewer authors
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
Nat. Genet. 43:1256-1261(2011)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26368816; DOI=10.1371/journal.pone.0133813; PMCID=PMC4569544
Lu-Yuan Li, Ana C. Paz, Breelyn A. Wilky, Britt Johnson, Karina Galoian, Andrew Rosenberg, Guo-Zhi Hu, Gabriel Tinoco, Olaf A. Bodamer, Jonathan C. Trent 2nd;
Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells.
PLoS ONE 10:e0133813.1-e0133813.19(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D605
Anatomy/cell type resources BTO; BTO_0005168
Biological sample resources BioSample; SAMN03470880
Chemistry resources PharmacoDB; JJ012_705_2019
Encyclopedic resources Wikidata; Q54898950
Experimental variables resources EFO; EFO_0006604
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM1676351
GEO; GSM1701681
Polymorphism and mutation databases Cosmic; 1602476
Cosmic; 1992323
IARC_TP53; 27035
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number28