Cellosaurus logo
expasy logo

Cellosaurus HPK-1A (CVCL_D890)

[Text version]
Cell line name HPK-1A
Synonyms HPK1A; HPK IA; HPKIA
Accession CVCL_D890
Resource Identification Initiative To cite this cell line use: HPK-1A (RRID:CVCL_D890)
Comments Virology: Contains 2 to 3 copies of the complete HPV16 genomes arranged in a head-to-tail fashion and integrated at a single chromosomal site.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D891 (HPK-1A-ras)CVCL_C8BL (HPK1A-AS)
Sex of cell Male
Category Transformed cell line
Publications

PubMed=2838778
Matthias Durst, Rule T. Dzarlieva-Petrusevska, Petra Boukamp, Norbert E. Fusenig, Lutz Gissmann;
Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.
Oncogene 1:251-256(1987)

PubMed=2556855; DOI=10.1016/0042-6822(89)90595-3
Matthias Durst, Dan Gallahan, Gilbert Jay, Johng Sik Rhim;
Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene.
Virology 173:767-771(1989)

DOI=10.1007/978-1-4612-0411-4_3
B. Lynn Allen-Hoffmann, Nader Sheibani, Jill S. Hatfield, Johng Sik Rhim;
Use of immortalized human keratinocytes for the study of squamous differentiation and mutagenesis.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.25-34; Humana Press; New York; USA (1990)

PubMed=1742725
Janet Henderson, Michael Sebag, Johng Sik Rhim, David Goltzman, Richard Kremer;
Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression.
Cancer Res. 51:6521-6528(1991)

PubMed=1618864; DOI=10.1016/S0021-9258(18)42258-2
Stephanie M. Kaiser, Pierre Laneuville, Suzanne Marie Bernier, Johng Sik Rhim, Richard Kremer, David Goltzman;
Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide.
J. Biol. Chem. 267:13623-13628(1992)

PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003
Markus Schmitt, Michael Pawlita;
The HPV transcriptome in HPV16 positive cell lines.
Mol. Cell. Probes 25:108-113(2011)

Cross-references
Anatomy/cell type resources BTO; BTO_0005276
Encyclopedic resources Wikidata; Q54890290
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number15