Cellosaurus logo
expasy logo

Cellosaurus HPK-1A (CVCL_D890)

[Text version]
Cell line name HPK-1A
Synonyms HPK1A; HPK IA; HPKIA
Accession CVCL_D890
Resource Identification Initiative To cite this cell line use: HPK-1A (RRID:CVCL_D890)
Comments Virology: Contains 2 to 3 copies of the complete HPV16 genomes arranged in a head-to-tail fashion and integrated at a single chromosomal site.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D891 (HPK-1A-ras)CVCL_C8BL (HPK1A-AS)
Sex of cell Male
Category Transformed cell line
Publications

PubMed=2838778
Durst M., Dzarlieva-Petrusevska R.T., Boukamp P., Fusenig N.E., Gissmann L.
Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.
Oncogene 1:251-256(1987)

PubMed=2556855; DOI=10.1016/0042-6822(89)90595-3
Durst M., Gallahan D., Jay G., Rhim J.S.
Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene.
Virology 173:767-771(1989)

DOI=10.1007/978-1-4612-0411-4_3
Allen-Hoffmann B.L., Sheibani N., Hatfield J.S., Rhim J.S.
Use of immortalized human keratinocytes for the study of squamous differentiation and mutagenesis.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.25-34; Humana Press; New York (1990)

PubMed=1742725
Henderson J., Sebag M., Rhim J.S., Goltzman D., Kremer R.
Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression.
Cancer Res. 51:6521-6528(1991)

PubMed=1618864; DOI=10.1016/S0021-9258(18)42258-2
Kaiser S.M., Laneuville P., Bernier S.M., Rhim J.S., Kremer R., Goltzman D.
Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide.
J. Biol. Chem. 267:13623-13628(1992)

PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003
Schmitt M., Pawlita M.
The HPV transcriptome in HPV16 positive cell lines.
Mol. Cell. Probes 25:108-113(2011)

Cross-references
Anatomy/cell type resources BTO; BTO:0005276
Encyclopedic resources Wikidata; Q54890290
Entry history
Entry creation22-Oct-2012
Last entry update29-Jun-2023
Version number13