ID   HPK-1A
AC   CVCL_D890
SY   HPK1A; HPK IA; HPKIA
DR   BTO; BTO:0005276
DR   Wikidata; Q54890290
RX   DOI=10.1007/978-1-4612-0411-4_3;
RX   PubMed=1618864;
RX   PubMed=1742725;
RX   PubMed=2838778;
RX   PubMed=2556855;
RX   PubMed=21439369;
CC   Virology: Contains 2 to 3 copies of the complete HPV16 genomes arranged in a head-to-tail fashion and integrated at a single chromosomal site.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 29-06-23; Version: 13
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RX   DOI=10.1007/978-1-4612-0411-4_3;
RA   Allen-Hoffmann B.L., Sheibani N., Hatfield J.S., Rhim J.S.;
RT   "Use of immortalized human keratinocytes for the study of squamous
RT   differentiation and mutagenesis.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.25-34; Humana Press; New York (1990).
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RX   PubMed=1618864; DOI=10.1016/S0021-9258(18)42258-2;
RA   Kaiser S.M., Laneuville P., Bernier S.M., Rhim J.S., Kremer R.,
RA   Goltzman D.;
RT   "Enhanced growth of a human keratinocyte cell line induced by
RT   antisense RNA for parathyroid hormone-related peptide.";
RL   J. Biol. Chem. 267:13623-13628(1992).
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RX   PubMed=1742725;
RA   Henderson J., Sebag M., Rhim J.S., Goltzman D., Kremer R.;
RT   "Dysregulation of parathyroid hormone-like peptide expression and
RT   secretion in a keratinocyte model of tumor progression.";
RL   Cancer Res. 51:6521-6528(1991).
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RX   PubMed=2838778;
RA   Durst M., Dzarlieva-Petrusevska R.T., Boukamp P., Fusenig N.E.,
RA   Gissmann L.;
RT   "Molecular and cytogenetic analysis of immortalized human primary
RT   keratinocytes obtained after transfection with human papillomavirus
RT   type 16 DNA.";
RL   Oncogene 1:251-256(1987).
//
RX   PubMed=2556855; DOI=10.1016/0042-6822(89)90595-3;
RA   Durst M., Gallahan D., Jay G., Rhim J.S.;
RT   "Glucocorticoid-enhanced neoplastic transformation of human
RT   keratinocytes by human papillomavirus type 16 and an activated ras
RT   oncogene.";
RL   Virology 173:767-771(1989).
//
RX   PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003;
RA   Schmitt M., Pawlita M.;
RT   "The HPV transcriptome in HPV16 positive cell lines.";
RL   Mol. Cell. Probes 25:108-113(2011).
//