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Cellosaurus M249 (CVCL_D755)

[Text version]
Cell line name M249
Accession CVCL_D755
Resource Identification Initiative To cite this cell line use: M249 (RRID:CVCL_D755)
Comments Doubling time: 21.2 hours (PubMed=20406486).
Omics: Transcriptome analysis by RNAseq.
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EI93 (M249 R4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

PubMed=20406486; DOI=10.1186/1479-5876-8-39
Sondergaard J.N., Nazarian R., Wang Q., Guo D.-L., Hsueh T., Mok S., Sazegar H., MacConaill L.E., Barretina J.G., Kehoe S.M., Attar N., von Euw E.M., Zuckerman J.E., Chmielowski B., Comin-Anduix B., Koya R.C., Mischel P.S., Lo R.S., Ribas A.
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.
J. Transl. Med. 8:39.1-39.11(2010)

PubMed=20689758; DOI=10.1593/neo.10414
Tap W.D., Gong K.-W., Dering J., Tseng Y., Ginther C., Pauletti G., Glaspy J.A., Essner R., Bollag G., Hirth P., Zhang C., Slamon D.J.
Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma.
Neoplasia 12:637-649(2010)

PubMed=22194965; DOI=10.1371/journal.pone.0028973
Atefi M., von Euw E.M., Attar N., Ng C., Chu C., Guo D.-L., Nazarian R., Chmielowski B., Glaspy J.A., Comin-Anduix B., Mischel P.S., Lo R.S., Ribas A.
Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.
PLoS ONE 6:E28973-E28973(2011)

PubMed=22515704; DOI=10.1186/1476-4598-11-22
von Euw E.M., Atefi M., Attar N., Chu C., Zachariah S., Burgess B.L., Mok S., Ng C., Wong D.J.L., Chmielowski B., Lichter D.I., Koya R.C., McCannel T.A., Izmailova E., Ribas A.
Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines.
Mol. Cancer 11:22.1-22.9(2012)

PubMed=24735930; DOI=10.1186/1476-4598-13-83
Lassen A., Atefi M., Robert L., Wong D.J.L., Cerniglia M., Comin-Anduix B., Ribas A.
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma.
Mol. Cancer 13:83.1-83.14(2014)

PubMed=29229836; DOI=10.1073/pnas.1712064115
Su Y.-P., Wei W., Robert L., Xue M., Tsoi J., Garcia-Diaz A., Homet Moreno B., Kim J., Ng R.H., Lee J.W., Koya R.C., Comin-Anduix B., Graeber T.G., Ribas A., Heath J.R.
Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.
Proc. Natl. Acad. Sci. U.S.A. 114:13679-13684(2017)

Cell line databases/resources cancercelllines; CVCL_D755
Encyclopedic resources Wikidata; Q54903562
Gene expression databases ArrayExpress; E-MTAB-5493
Polymorphism and mutation databases Cosmic; 1425353
Cosmic; 1459652
Cosmic; 1545618
Cosmic; 1665014
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number13