Cellosaurus logo
expasy logo

Cellosaurus M249 (CVCL_D755)

[Text version]
Cell line name M249
Accession CVCL_D755
Resource Identification Initiative To cite this cell line use: M249 (RRID:CVCL_D755)
Comments Doubling time: 21.2 hours (PubMed=20406486).
Omics: Transcriptomics; RNAseq.
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EI93 (M249 R4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=20406486; DOI=10.1186/1479-5876-8-39; PMCID=PMC2876068
Jonas Norskov Sondergaard, Ramin Nazarian, Qi Wang, De-Liang Guo, Teli Hsueh, Stephen Mok, Hooman Sazegar, Laura E. MacConaill, Jordi Ginesta Barretina, Sarah M. Kehoe, Narsis Attar ...Show all 19 authors... , Erika Maria von Euw, Jonathan E. Zuckerman, Bartosz Chmielowski, Begonya Comin-Anduix, Richard C. Koya, Paul Salomon Mischel, Roger S. Lo, Antoni Ribas; Show fewer authors
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.
J. Transl. Med. 8:39.1-39.11(2010)

PubMed=20689758; DOI=10.1593/neo.10414; PMCID=PMC2915408
William Douglas Tap, Ke-Wei Gong, Judy Dering, Yiou Tseng, Charles Ginther, Giovanni Pauletti, John A. Glaspy, Richard Essner, Gideon Bollag, Peter Hirth, Chao Zhang, Dennis Joseph Slamon;
Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma.
Neoplasia 12:637-649(2010)

PubMed=22194965; DOI=10.1371/journal.pone.0028973; PMCID=PMC3237573
Mohammad Atefi, Erika Maria von Euw, Narsis Attar, Charles Ng, Connie Chu, De-Liang Guo, Ramin Nazarian, Bartosz Chmielowski, John A. Glaspy, Begonya Comin-Anduix, Paul Salomon Mischel ...Show all 13 authors... , Roger S. Lo, Antoni Ribas; Show fewer authors
Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.
PLoS ONE 6:e28973.1-e28973.12(2011)

PubMed=22515704; DOI=10.1186/1476-4598-11-22; PMCID=PMC3444881
Erika Maria von Euw, Mohammad Atefi, Narsis Attar, Connie Chu, Sybil Zachariah, Barry L. Burgess, Stephen Mok, Charles Ng, Deborah J.L. Wong, Bartosz Chmielowski, David I. Lichter ...Show all 15 authors... , Richard C. Koya, Tara A. McCannel, Elena Izmailova, Antoni Ribas; Show fewer authors
Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines.
Mol. Cancer 11:22.1-22.9(2012)

PubMed=24735930; DOI=10.1186/1476-4598-13-83; PMCID=PMC4021505
Amanda Lassen, Mohammad Atefi, Lidia Robert, Deborah J.L. Wong, Michael Cerniglia, Begonya Comin-Anduix, Antoni Ribas;
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma.
Mol. Cancer 13:83.1-83.14(2014)

PubMed=29229836; DOI=10.1073/pnas.1712064115; PMCID=PMC5748184
Ya-Peng Su, Wei Wei, Lidia Robert, Min Xue, Jennifer Tsoi, Angel Garcia-Diaz, Blanca Homet Moreno, Jungwoo Kim, Rachel Hin-Ying Ng, Jihoon W. Lee, Richard C. Koya ...Show all 15 authors... , Begonya Comin-Anduix, Thomas G. Graeber, Antoni Ribas, James Richard Heath; Show fewer authors
Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.
Proc. Natl. Acad. Sci. U.S.A. 114:13679-13684(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D755
Encyclopedic resources Wikidata; Q54903562
Experimental variables resources EFO; EFO_0022586
Gene expression databases ArrayExpress; E-MTAB-5493
Polymorphism and mutation databases Cosmic; 1425353
Cosmic; 1459652
Cosmic; 1545618
Cosmic; 1665014
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number16