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Cellosaurus M249 R4 (CVCL_EI93)

[Text version]
Cell line name M249 R4
Synonyms M249-AR4; M249AR4
Accession CVCL_EI93
Resource Identification Initiative To cite this cell line use: M249 R4 (RRID:CVCL_EI93)
Comments Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variations
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D755 (M249)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=21107323; DOI=10.1038/nature09626; PMCID=PMC3143360
Ramin Nazarian, Hu-Bing Shi, Qi Wang, Xiang-Ju Kong, Richard C. Koya, Hane Lee, Zu-Gen Chen, Mi-Kyung Lee, Narsis Attar, Hooman Sazegar, Thinle Chodon ...Show all 16 authors... , Stanley F. Nelson, Grant A. McArthur, Jeffrey A. Sosman, Antoni Ribas, Roger S. Lo; Show fewer authors
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
Nature 468:973-977(2010)

PubMed=22194965; DOI=10.1371/journal.pone.0028973; PMCID=PMC3237573
Mohammad Atefi, Erika Maria von Euw, Narsis Attar, Charles Ng, Connie Chu, De-Liang Guo, Ramin Nazarian, Bartosz Chmielowski, John A. Glaspy, Begonya Comin-Anduix, Paul Salomon Mischel ...Show all 13 authors... , Roger S. Lo, Antoni Ribas; Show fewer authors
Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.
PLoS ONE 6:e28973.1-e28973.12(2011)

PubMed=25645078; DOI=10.1186/s12943-015-0293-5; PMCID=PMC4320814
Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah J.L. Wong, Amanda Lassen, Michael Cerniglia, Helena Escuin-Ordinas, David Foulad, Begonya Comin-Anduix, Thomas G. Graeber, Antoni Ribas;
Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
Mol. Cancer 14:27.1-27.12(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI93
Encyclopedic resources Wikidata; Q54903563
Polymorphism and mutation databases Cosmic; 1545619
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number12