ID   M249
AC   CVCL_D755
DR   EFO; EFO_0022586
DR   ArrayExpress; E-MTAB-5493
DR   cancercelllines; CVCL_D755
DR   Cosmic; 1425353
DR   Cosmic; 1459652
DR   Cosmic; 1545618
DR   Cosmic; 1665014
DR   Wikidata; Q54903562
RX   PubMed=20406486;
RX   PubMed=20689758;
RX   PubMed=22194965;
RX   PubMed=22515704;
RX   PubMed=24735930;
RX   PubMed=29229836;
CC   Doubling time: 21.2 hours (PubMed=20406486).
CC   Sequence variation: Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (PubMed=20406486; PubMed=22194965).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=20406486; PubMed=22194965).
CC   Omics: Transcriptomics; RNAseq.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 16
//
RX   PubMed=20406486; DOI=10.1186/1479-5876-8-39; PMCID=PMC2876068;
RA   Sondergaard, Jonas Norskov
RA   Nazarian, Ramin
RA   Wang, Qi
RA   Guo, De-Liang
RA   Hsueh, Teli
RA   Mok, Stephen
RA   Sazegar, Hooman
RA   MacConaill, Laura E.
RA   Barretina, Jordi Ginesta
RA   Kehoe, Sarah M.
RA   Attar, Narsis
RA   von Euw, Erika Maria
RA   Zuckerman, Jonathan E.
RA   Chmielowski, Bartosz
RA   Comin-Anduix, Begonya
RA   Koya, Richard C.
RA   Mischel, Paul Salomon
RA   Lo, Roger S.
RA   Ribas, Antoni
RT   "Differential sensitivity of melanoma cell lines with BRAFV600E
RT   mutation to the specific Raf inhibitor PLX4032.";
RL   J. Transl. Med. 8:39.1-39.11(2010).
//
RX   PubMed=20689758; DOI=10.1593/neo.10414; PMCID=PMC2915408;
RA   Tap, William Douglas
RA   Gong, Ke-Wei
RA   Dering, Judy
RA   Tseng, Yiou
RA   Ginther, Charles
RA   Pauletti, Giovanni
RA   Glaspy, John A.
RA   Essner, Richard
RA   Bollag, Gideon
RA   Hirth, Peter
RA   Zhang, Chao
RA   Slamon, Dennis Joseph
RT   "Pharmacodynamic characterization of the efficacy signals due to
RT   selective BRAF inhibition with PLX4032 in malignant melanoma.";
RL   Neoplasia 12:637-649(2010).
//
RX   PubMed=22194965; DOI=10.1371/journal.pone.0028973; PMCID=PMC3237573;
RA   Atefi, Mohammad
RA   von Euw, Erika Maria
RA   Attar, Narsis
RA   Ng, Charles
RA   Chu, Connie
RA   Guo, De-Liang
RA   Nazarian, Ramin
RA   Chmielowski, Bartosz
RA   Glaspy, John A.
RA   Comin-Anduix, Begonya
RA   Mischel, Paul Salomon
RA   Lo, Roger S.
RA   Ribas, Antoni
RT   "Reversing melanoma cross-resistance to BRAF and MEK inhibitors by
RT   co-targeting the AKT/mTOR pathway.";
RL   PLoS ONE 6:e28973.1-e28973.12(2011).
//
RX   PubMed=22515704; DOI=10.1186/1476-4598-11-22; PMCID=PMC3444881;
RA   von Euw, Erika Maria
RA   Atefi, Mohammad
RA   Attar, Narsis
RA   Chu, Connie
RA   Zachariah, Sybil
RA   Burgess, Barry L.
RA   Mok, Stephen
RA   Ng, Charles
RA   Wong, Deborah J.L.
RA   Chmielowski, Bartosz
RA   Lichter, David I.
RA   Koya, Richard C.
RA   McCannel, Tara A.
RA   Izmailova, Elena
RA   Ribas, Antoni
RT   "Antitumor effects of the investigational selective MEK inhibitor
RT   TAK733 against cutaneous and uveal melanoma cell lines.";
RL   Mol. Cancer 11:22.1-22.9(2012).
//
RX   PubMed=24735930; DOI=10.1186/1476-4598-13-83; PMCID=PMC4021505;
RA   Lassen, Amanda
RA   Atefi, Mohammad
RA   Robert, Lidia
RA   Wong, Deborah J.L.
RA   Cerniglia, Michael
RA   Comin-Anduix, Begonya
RA   Ribas, Antoni
RT   "Effects of AKT inhibitor therapy in response and resistance to BRAF
RT   inhibition in melanoma.";
RL   Mol. Cancer 13:83.1-83.14(2014).
//
RX   PubMed=29229836; DOI=10.1073/pnas.1712064115; PMCID=PMC5748184;
RA   Su, Ya-Peng
RA   Wei, Wei
RA   Robert, Lidia
RA   Xue, Min
RA   Tsoi, Jennifer
RA   Garcia-Diaz, Angel
RA   Homet Moreno, Blanca
RA   Kim, Jungwoo
RA   Ng, Rachel Hin-Ying
RA   Lee, Jihoon W.
RA   Koya, Richard C.
RA   Comin-Anduix, Begonya
RA   Graeber, Thomas G.
RA   Ribas, Antoni
RA   Heath, James Richard
RT   "Single-cell analysis resolves the cell state transition and signaling
RT   dynamics associated with melanoma drug-induced resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:13679-13684(2017).
//