| Cell line name |
A-673 EHD1 KO |
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| Synonyms |
EHD1-KO A673 |
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| Accession |
CVCL_D6TY |
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| Resource Identification Initiative |
To cite this cell line use: A-673 EHD1 KO (RRID:CVCL_D6TY) |
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| Comments |
Problematic cell line: Misclassified. Parent cell line (A-673) was originally thought to be a rhabdomyosarcoma cell line but is an Ewing sarcoma cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3242; EHD1.
Derived from site: In situ; Muscle; UBERON=UBERON_0001630. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA); Zygosity=Homozygous (from parent cell line).
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| Disease |
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0080 (A-673) |
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| Sex of cell |
Female |
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| Age at sampling |
15Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=37474760; DOI=10.1038/s42003-023-05125-1; PMCID=PMC10359273
Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Hai-Tao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Isidro Machado ...Show all 19 authors... , Katia Scotlandi, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, Michael Jordan Rowley, Vimla Band, Bhopal C. Mohapatra, Hamid Band; Show fewer authors
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Commun. Biol. 6:758.1-758.21(2023) |
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| Entry history |
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| Entry creation | 10-Sep-2024 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 2 |
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