ID   A-673 EHD1 KO
AC   CVCL_D6TY
SY   EHD1-KO A673
RX   PubMed=37474760;
CC   Problematic cell line: Misclassified. Parent cell line (A-673) was originally thought to be a rhabdomyosarcoma cell line but is an Ewing sarcoma cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3242; EHD1.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Muscle; UBERON=UBERON_0001630.
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0080 ! A-673
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 19-12-24; Version: 2
//
RX   PubMed=37474760; DOI=10.1038/s42003-023-05125-1; PMCID=PMC10359273;
RA   Chakraborty, Sukanya
RA   Bhat, Aaqib M.
RA   Mushtaq, Insha
RA   Luan, Hai-Tao
RA   Kalluchi, Achyuth
RA   Mirza, Sameer
RA   Storck, Matthew D.
RA   Chaturvedi, Nagendra
RA   Lopez-Guerrero, Jose Antonio
RA   Llombart-Bosch, Antonio
RA   Machado, Isidro
RA   Scotlandi, Katia
RA   Meza, Jane L.
RA   Ghosal, Gargi
RA   Coulter, Donald W.
RA   Rowley, Michael Jordan
RA   Band, Vimla
RA   Mohapatra, Bhopal C.
RA   Band, Hamid
RT   "EHD1-dependent traffic of IGF-1 receptor to the cell surface is
RT   essential for Ewing sarcoma tumorigenesis and metastasis.";
RL   Commun. Biol. 6:758.1-758.21(2023).
//