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Cellosaurus MRC-5V1 (CVCL_D690)

[Text version]
Cell line name MRC-5V1
Synonyms MRC5-V1; MRC5V1
Accession CVCL_D690
Resource Identification Initiative To cite this cell line use: MRC-5V1 (RRID:CVCL_D690)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
Cell type: Fibroblast of lung; CL=CL_0002553.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0440 (MRC-5)
Sex of cell Male
Age at sampling 14FW
Category Transformed cell line
Publications

PubMed=6313714; DOI=10.1242/jcs.63.1.77
Lily I. Huschtscha, Robin Holliday;
Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts.
J. Cell Sci. 63:77-99(1983)

PubMed=2821020; DOI=10.1242/jcs.1984.Supplement_6.8
Michael H.L. Green, Jill E. Lowe, Colin Francis Arlett, Susan A. Harcourt, Julian F. Burke, Michael R. James, Alan R. Lehmann, Susan Povey;
A gamma-ray-resistant derivative of an ataxia telangiectasia cell line obtained following DNA-mediated gene transfer.
J. Cell Sci. Suppl. 6:127-137(1987)

PubMed=2903889; DOI=10.1080/09553008814552321
Colin Francis Arlett, Michael H.L. Green, Anne Priestley, Susan A. Harcourt, Lynne V. Mayne;
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=3180052
Alan R. Lehmann, Anne Elizabeth Willis, Bernard C. Broughton, Michael R. James, Herdis Steingrimsdottir, Susan A. Harcourt, Colin Francis Arlett, Tomas Robert Lindahl;
Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome.
Cancer Res. 48:6343-6347(1988)

PubMed=8055625; DOI=10.1093/carcin/15.8.1493
Mauro Mezzina, Eric Eveno, Odile Chevallier-Lagente, Annie Benoit, Madeleine Carreau, Wim Vermeulen, Jan Hendrik Jozef Hoeijmakers, Miria Stefanini, Alan R. Lehmann, Christine A. Weber, Alain Sarasin;
Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells.
Carcinogenesis 15:1493-1498(1994)

PubMed=7563073; DOI=10.1006/jmbi.1995.0519
Claire Marionnet, Annie Benoit, Simone Benhamou, Alain Sarasin, Anne Stary;
Characteristics of UV-induced mutation spectra in human XP-D/ERCC2 gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.
J. Mol. Biol. 252:550-562(1995)

PubMed=8824772; DOI=10.1016/0300-9084(95)90011-x
Eric Eveno, Xavier Quilliet, Odile Chevallier-Lagente, Leela Daya-Grosjean, Anne Stary, Lin Zeng, Annie Benoit, Elena Savini, Giovanni Ciarrocchi, Patricia Kannouche, Bernard Salles ...Show all 13 authors... , Alain Sarasin, Mauro Mezzina; Show fewer authors
Stable SV40-transformation and characterisation of some DNA repair properties of fibroblasts from a trichothiodystrophy patient.
Biochimie 77:906-912(1995)

PubMed=21528266; DOI=10.3892/ijo.11.4.717
Evangelos Kolettas, Demetrios A. Spandidos, Robert F. Rosenberger;
SV40-transformation of embryonic human diploid fibroblasts results in multiple molecular changes.
Int. J. Oncol. 11:717-725(1997)

CLPUB00712
Jeremy David Henson;
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

PubMed=16714754; DOI=10.1259/bjr/83726649
Colin Francis Arlett, Piers N. Plowman, Paul Bryan Rogers, Christopher N. Parris, Fatemeh Abbaszadeh, Michael H.L. Green, Trevor J. McMillan, Cyd Bush, Nicolas Foray, Alan R. Lehmann;
Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum.
Br. J. Radiol. 79:510-517(2006)

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references
Anatomy/cell type resources BTO; BTO_0005066
Encyclopedic resources Wikidata; Q54906594
Experimental variables resources EFO; EFO_0022549
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number18