ID   MRC-5V1
AC   CVCL_D690
SY   MRC5-V1; MRC5V1
DR   BTO; BTO_0005066
DR   EFO; EFO_0022549
DR   Wikidata; Q54906594
RX   CelloPub=CLPUB00712;
RX   PubMed=2821020;
RX   PubMed=2903889;
RX   PubMed=3180052;
RX   PubMed=6313714;
RX   PubMed=7563073;
RX   PubMed=8055625;
RX   PubMed=8824772;
RX   PubMed=16714754;
RX   PubMed=19935656;
RX   PubMed=21528266;
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0440 ! MRC-5
SX   Male
AG   14FW
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 18
//
RX   PubMed=16714754; DOI=10.1259/bjr/83726649;
RA   Arlett, Colin Francis
RA   Plowman, Piers N.
RA   Rogers, Paul Bryan
RA   Parris, Christopher N.
RA   Abbaszadeh, Fatemeh
RA   Green, Michael H.L.
RA   McMillan, Trevor J.
RA   Bush, Cyd
RA   Foray, Nicolas
RA   Lehmann, Alan Robert
RT   "Clinical and cellular ionizing radiation sensitivity in a patient
RT   with xeroderma pigmentosum.";
RL   Br. J. Radiol. 79:510-517(2006).
//
RX   PubMed=21528266; DOI=10.3892/ijo.11.4.717;
RA   Kolettas, Evangelos
RA   Spandidos, Demetrios A.
RA   Rosenberger, Robert F.
RT   "SV40-transformation of embryonic human diploid fibroblasts results in
RT   multiple molecular changes.";
RL   Int. J. Oncol. 11:717-725(1997).
//
RX   PubMed=8055625; DOI=10.1093/carcin/15.8.1493;
RA   Mezzina, Mauro
RA   Eveno, Eric
RA   Chevallier-Lagente, Odile
RA   Benoit, Annie
RA   Carreau, Madeleine
RA   Vermeulen, Wim
RA   Hoeijmakers, Jan Hendrik Jozef
RA   Stefanini, Miria
RA   Lehmann, Alan Robert
RA   Weber, Christine A.
RA   Sarasin, Alain
RT   "Correction by the ERCC2 gene of UV sensitivity and repair deficiency
RT   phenotype in a subset of trichothiodystrophy cells.";
RL   Carcinogenesis 15:1493-1498(1994).
//
RX   CelloPub=CLPUB00712;
RA   Henson, Jeremy David
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006); University of Sydney; Sydney; Australia.
//
RX   PubMed=3180052;
RA   Lehmann, Alan Robert
RA   Willis, Anne Elizabeth
RA   Broughton, Bernard C.
RA   James, Michael R.
RA   Steingrimsdottir, Herdis
RA   Harcourt, Susan A.
RA   Arlett, Colin Francis
RA   Lindahl, Tomas Robert
RT   "Relation between the human fibroblast strain 46BR and cell lines
RT   representative of Bloom's syndrome.";
RL   Cancer Res. 48:6343-6347(1988).
//
RX   PubMed=8824772; DOI=10.1016/0300-9084(95)90011-x;
RA   Eveno, Eric
RA   Quilliet, Xavier
RA   Chevallier-Lagente, Odile
RA   Daya-Grosjean, Leela
RA   Stary, Anne
RA   Zeng, Lin
RA   Benoit, Annie
RA   Savini, Elena
RA   Ciarrocchi, Giovanni
RA   Kannouche, Patricia
RA   Salles, Bernard
RA   Sarasin, Alain
RA   Mezzina, Mauro
RT   "Stable SV40-transformation and characterisation of some DNA repair
RT   properties of fibroblasts from a trichothiodystrophy patient.";
RL   Biochimie 77:906-912(1995).
//
RX   PubMed=7563073; DOI=10.1006/jmbi.1995.0519;
RA   Marionnet, Claire
RA   Benoit, Annie
RA   Benhamou, Simone
RA   Sarasin, Alain
RA   Stary, Anne
RT   "Characteristics of UV-induced mutation spectra in human XP-D/ERCC2
RT   gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.";
RL   J. Mol. Biol. 252:550-562(1995).
//
RX   PubMed=2821020; DOI=10.1242/jcs.1984.Supplement_6.8;
RA   Green, Michael H.L.
RA   Lowe, Jill E.
RA   Arlett, Colin Francis
RA   Harcourt, Susan A.
RA   Burke, Julian F.
RA   James, Michael R.
RA   Lehmann, Alan Robert
RA   Povey, Susan
RT   "A gamma-ray-resistant derivative of an ataxia telangiectasia cell
RT   line obtained following DNA-mediated gene transfer.";
RL   J. Cell Sci. Suppl. 6:127-137(1987).
//
RX   PubMed=6313714; DOI=10.1242/jcs.63.1.77;
RA   Huschtscha, Lily I.
RA   Holliday, Robin
RT   "Limited and unlimited growth of SV40-transformed cells from human
RT   diploid MRC-5 fibroblasts.";
RL   J. Cell Sci. 63:77-99(1983).
//
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson, Jeremy David
RA   Cao, Ying
RA   Huschtscha, Lily I.
RA   Chang, Andy C.-M.
RA   Au, Amy Y.M.
RA   Pickett, Hilda A.
RA   Reddel, Roger Robert
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
//
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett, Colin Francis
RA   Green, Michael H.L.
RA   Priestley, Anne
RA   Harcourt, Susan A.
RA   Mayne, Lynne V.
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
//