ID   MRC-5V1
AC   CVCL_D690
SY   MRC5-V1; MRC5V1
DR   BTO; BTO:0005066
DR   Wikidata; Q54906594
RX   CelloPub=CLPUB00712;
RX   PubMed=2821020;
RX   PubMed=2903889;
RX   PubMed=3180052;
RX   PubMed=6313714;
RX   PubMed=7563073;
RX   PubMed=8055625;
RX   PubMed=8824772;
RX   PubMed=16714754;
RX   PubMed=19935656;
RX   PubMed=21528266;
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0440 ! MRC-5
SX   Male
AG   14FW
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 29-06-23; Version: 16
RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006), University of Sydney, Australia.
RX   PubMed=2821020; DOI=10.1242/jcs.1984.Supplement_6.8;
RA   Green M.H.L., Lowe J.E., Arlett C.F., Harcourt S.A., Burke J.F.,
RA   James M.R., Lehmann A.R., Povey S.;
RT   "A gamma-ray-resistant derivative of an ataxia telangiectasia cell
RT   line obtained following DNA-mediated gene transfer.";
RL   J. Cell Sci. Suppl. 6:127-137(1987).
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.;
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
RX   PubMed=3180052;
RA   Lehmann A.R., Willis A.E., Broughton B.C., James M.R.,
RA   Steingrimsdottir H., Harcourt S.A., Arlett C.F., Lindahl T.R.;
RT   "Relation between the human fibroblast strain 46BR and cell lines
RT   representative of Bloom's syndrome.";
RL   Cancer Res. 48:6343-6347(1988).
RX   PubMed=6313714; DOI=10.1242/jcs.63.1.77;
RA   Huschtscha L.I., Holliday R.;
RT   "Limited and unlimited growth of SV40-transformed cells from human
RT   diploid MRC-5 fibroblasts.";
RL   J. Cell Sci. 63:77-99(1983).
RX   PubMed=7563073; DOI=10.1006/jmbi.1995.0519;
RA   Marionnet C., Benoit A., Benhamou S., Sarasin A., Stary A.;
RT   "Characteristics of UV-induced mutation spectra in human XP-D/ERCC2
RT   gene-mutated xeroderma pigmentosum and trichothiodystrophy cells.";
RL   J. Mol. Biol. 252:550-562(1995).
RX   PubMed=8055625; DOI=10.1093/carcin/15.8.1493;
RA   Mezzina M., Eveno E., Chevallier-Lagente O., Benoit A., Carreau M.,
RA   Vermeulen W., Hoeijmakers J.H.J., Stefanini M., Lehmann A.R.,
RA   Weber C.A., Sarasin A.;
RT   "Correction by the ERCC2 gene of UV sensitivity and repair deficiency
RT   phenotype in a subset of trichothiodystrophy cells.";
RL   Carcinogenesis 15:1493-1498(1994).
RX   PubMed=8824772; DOI=10.1016/0300-9084(95)90011-x;
RA   Eveno E., Quilliet X., Chevallier-Lagente O., Daya-Grosjean L.,
RA   Stary A., Zeng L., Benoit A., Savini E., Ciarrocchi G., Kannouche P.,
RA   Salles B., Sarasin A., Mezzina M.;
RT   "Stable SV40-transformation and characterisation of some DNA repair
RT   properties of fibroblasts from a trichothiodystrophy patient.";
RL   Biochimie 77:906-912(1995).
RX   PubMed=16714754; DOI=10.1259/bjr/83726649;
RA   Arlett C.F., Plowman P.N., Rogers P.B., Parris C.N., Abbaszadeh F.,
RA   Green M.H.L., McMillan T.J., Bush C., Foray N., Lehmann A.R.;
RT   "Clinical and cellular ionizing radiation sensitivity in a patient
RT   with xeroderma pigmentosum.";
RL   Br. J. Radiol. 79:510-517(2006).
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
RX   PubMed=21528266; DOI=10.3892/ijo.11.4.717;
RA   Kolettas E., Spandidos D.A., Rosenberger R.F.;
RT   "SV40-transformation of embryonic human diploid fibroblasts results in
RT   multiple molecular changes.";
RL   Int. J. Oncol. 11:717-725(1997).