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Cellosaurus RWLeu-4 (CVCL_D591)

[Text version]
Cell line name RWLeu-4
Synonyms RWLEU-4; RWLeu 4; RWLeu4; Roger Williams Leukemia-4
Accession CVCL_D591
Resource Identification Initiative To cite this cell line use: RWLeu-4 (RRID:CVCL_D591)
Comments Characteristics: Proliferation inhibited by vitamin D3 (PubMed=1372318; PubMed=7994044).
Doubling time: 33 hours (CelloPub=CLPUB00106); 25-26 hours (PubMed=2159372).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=10071072; PubMed=10576511).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D592 (JMRD3)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

CLPUB00106
Michael C. Wiemann, Ann B. Hollmann, Marshall R. Posner;
Establishment of a new Philadelphia chromosome-positive human chronic myeloid leukemia cell line.
Clin. Res. 33:460A-460A(1985)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Armand Keating;
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=2159372
Stephen R. Lasky, William Bell, Richard D. Huhn, Marshall R. Posner, Michael C. Wiemann, Paul Calabresi, Charles Eil;
Effects of 1 alpha, 25-dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu-4.
Cancer Res. 50:3087-3094(1990)

PubMed=1372318; DOI=10.1007/BF01410133
Jeffrey William Clark, Marshall R. Posner, Jean M. Marsella, Anabel Santos, Milan R. Uskokovic, Charles Eil, Stephen R. Lasky;
Effects of analogs of 1,25(OH)2 vitamin D3 on the proliferation and differentiation of the human chronic myelogenous leukemia cell line, RWLeu-4.
J. Cancer Res. Clin. Oncol. 118:190-194(1992)

PubMed=7994044; DOI=10.1182/blood.V84.12.4283.bloodjournal84124283
Stephen R. Lasky, Marshall R. Posner, Keigo Iwata, Anabel Santos-Moore, Andrew Yen, Varman Samuel, Jeffrey William Clark, Abby Lee Maizel;
Characterization of a vitamin D3-resistant human chronic myelogenous leukemia cell line.
Blood 84:4283-4294(1994)

PubMed=8635507; DOI=10.1006/excr.1996.0165
Keigo Iwata, Nicola Kouttab, Haruki Ogata, John W. Morgan, Abby Lee Maizel, Stephen R. Lasky;
Differential regulation of vitamin D receptors in clonal populations of a chronic myelogenous leukemia cell line.
Exp. Cell Res. 225:143-150(1996)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Cord C. Uphoff, Silke Habig, Severine Fombonne, Yoshinobu Matsuo, Hans Gunther Drexler;
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

Cross-references
Anatomy/cell type resources BTO; BTO_0005332
Chemistry resources ChEMBL-Cells; CHEMBL3307431
ChEMBL-Targets; CHEMBL614885
PubChem_Cell_line; CVCL_D591
Encyclopedic resources Wikidata; Q54951494
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number21