ID   RWLeu-4
AC   CVCL_D591
SY   RWLEU-4; RWLeu 4; RWLeu4; Roger Williams Leukemia-4
DR   BTO; BTO_0005332
DR   ChEMBL-Cells; CHEMBL3307431
DR   ChEMBL-Targets; CHEMBL614885
DR   PubChem_Cell_line; CVCL_D591
DR   Wikidata; Q54951494
RX   CelloPub=CLPUB00106;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1372318;
RX   PubMed=2159372;
RX   PubMed=3332852;
RX   PubMed=7994044;
RX   PubMed=8635507;
RX   PubMed=10071072;
RX   PubMed=10576511;
CC   Characteristics: Proliferation inhibited by vitamin D3 (PubMed=1372318; PubMed=7994044).
CC   Doubling time: 33 hours (CelloPub=CLPUB00106); 25-26 hours (PubMed=2159372).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=10071072; PubMed=10576511).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 21
//
RX   CelloPub=CLPUB00106;
RA   Wiemann M.C., Hollmann A.B., Posner M.R.;
RT   "Establishment of a new Philadelphia chromosome-positive human chronic
RT   myeloid leukemia cell line.";
RL   Clin. Res. 33:460A-460A(1985).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1372318; DOI=10.1007/BF01410133;
RA   Clark J.W., Posner M.R., Marsella J.M., Santos A., Uskokovic M.R.,
RA   Eil C., Lasky S.R.;
RT   "Effects of analogs of 1,25(OH)2 vitamin D3 on the proliferation and
RT   differentiation of the human chronic myelogenous leukemia cell line,
RT   RWLeu-4.";
RL   J. Cancer Res. Clin. Oncol. 118:190-194(1992).
//
RX   PubMed=2159372;
RA   Lasky S.R., Bell W., Huhn R.D., Posner M.R., Wiemann M.C., Calabresi P.,
RA   Eil C.;
RT   "Effects of 1 alpha, 25-dihydroxyvitamin D3 on the human chronic
RT   myelogenous leukemia cell line RWLeu-4.";
RL   Cancer Res. 50:3087-3094(1990).
//
RX   PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9;
RA   Keating A.;
RT   "Ph positive CML cell lines.";
RL   Baillieres Clin. Haematol. 1:1021-1029(1987).
//
RX   PubMed=7994044; DOI=10.1182/blood.V84.12.4283.bloodjournal84124283;
RA   Lasky S.R., Posner M.R., Iwata K., Santos-Moore A., Yen A., Samuel V.,
RA   Clark J.W., Maizel A.L.;
RT   "Characterization of a vitamin D3-resistant human chronic myelogenous
RT   leukemia cell line.";
RL   Blood 84:4283-4294(1994).
//
RX   PubMed=8635507; DOI=10.1006/excr.1996.0165;
RA   Iwata K., Kouttab N., Ogata H., Morgan J.W., Maizel A.L., Lasky S.R.;
RT   "Differential regulation of vitamin D receptors in clonal populations
RT   of a chronic myelogenous leukemia cell line.";
RL   Exp. Cell Res. 225:143-150(1996).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.;
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//