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Cellosaurus SF-xL (CVCL_D590)

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Cell line name SF-xL
Synonyms SFxl
Accession CVCL_D590
Resource Identification Initiative To cite this cell line use: SF-xL (RRID:CVCL_D590)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:992; BCL2L1 (Note=Isoform Bcl-xL).
Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Unspecified (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6948 (SF188)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=19033189; DOI=10.1073/pnas.0810199105; PMCID=PMC2596212
David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso, Nabil Sayed, Xiao-Yong Zhang, Harla K. Pfeiffer, Ilana Nissim, Evgueni Daikhin, Marc Yudkoff, Steven B. McMahon, Craig B. Thompson;
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.
Proc. Natl. Acad. Sci. U.S.A. 105:18782-18787(2008)

PubMed=21555572; DOI=10.1073/pnas.1016627108; PMCID=PMC3102381
Tzu-Ling Cheng, Jessica Sudderth, Chen-Dong Yang, Andrew R. Mullen, Eunsook S. Jin, Jose M. Mates, Ralph J. DeBerardinis;
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
Proc. Natl. Acad. Sci. U.S.A. 108:8674-8679(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D590
Anatomy/cell type resources BTO; BTO_0005311
Encyclopedic resources Wikidata; Q54952882
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number13