ID   SF-xL
AC   CVCL_D590
SY   SFxl
DR   BTO; BTO_0005311
DR   cancercelllines; CVCL_D590
DR   Wikidata; Q54952882
RX   PubMed=19033189;
RX   PubMed=21555572;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:992; BCL2L1 (Note=Isoform Bcl-xL).
CC   Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6948 ! SF188
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 13
//
RX   PubMed=19033189; DOI=10.1073/pnas.0810199105; PMCID=PMC2596212;
RA   Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.-Y.,
RA   Pfeiffer H.K., Nissim I., Daikhin E., Yudkoff M., McMahon S.B.,
RA   Thompson C.B.;
RT   "Myc regulates a transcriptional program that stimulates mitochondrial
RT   glutaminolysis and leads to glutamine addiction.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:18782-18787(2008).
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RX   PubMed=21555572; DOI=10.1073/pnas.1016627108; PMCID=PMC3102381;
RA   Cheng T.-L., Sudderth J., Yang C.-D., Mullen A.R., Jin E.S., Mates J.M.,
RA   DeBerardinis R.J.;
RT   "Pyruvate carboxylase is required for glutamine-independent growth of
RT   tumor cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:8674-8679(2011).
//