Cellosaurus RT4-54 (CVCL_D3XY)
| Cell line name | RT4-54 |
|---|---|
| Synonyms | RT4-D6P2T clone 54 |
| Accession | CVCL_D3XY |
| Resource Identification Initiative | To cite this cell line use: RT4-54 (RRID:CVCL_D3XY) |
| Comments | Characteristics: Expression of NF2 is doxycycline-inducible as the parent cell line was transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16 (PubMed=11316791). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7773; NF2. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Arg360del). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU). Derived from site: In situ; Peripheral nervous system, sciatic nerve; UBERON=UBERON_0001322. Cell type: Schwann cell; CL=CL_0002573. |
| Disease | Rat malignant schwannoma (NCIt: C60465) |
| Species of origin | Rattus norvegicus (Rat)
(NCBI Taxonomy: 10116)
Breed/subspecies: BDIX; RS=RS_0000091. |
| Hierarchy | Parent: CVCL_4006 (RT4-D6P2T) |
| Category | Cancer cell line |
| Publications | PubMed=11316791; DOI=10.1101/gad.189601; PMCID=PMC312675 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q127384097 |
| Entry history | |
| Entry creation | 30-Jan-2024 |
| Last entry update | 14-Aug-2025 |
| Version number | 5 |