| Cell line name |
LN229/EGFR |
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| Accession |
CVCL_D2SN |
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| Resource Identification Initiative |
To cite this cell line use: LN229/EGFR (RRID:CVCL_D2SN) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR (Note=With a N-terminal GVAMPGAEDDVV = PA-tag and a C-terminal with a C-terminal DMVNPGLEDRIE = RAP-tag and GDGMVPPGIEDK = MAP-tag).
Derived from site: In situ; Brain, right frontal parieto-occipital cortex. |
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| Sequence variations |
- Mutation; HGNC; HGNC:6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0393 (LN-229) |
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| Sex of cell |
Female |
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| Age at sampling |
60Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=29090976; DOI=10.1089/mab.2017.0042; PMCID=PMC6975130
Shunsuke Itai, Shinji Yamada, Mika Kato Kaneko, Yao-Wen Chang, Hiroyuki Harada, Yukinari Kato;
Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity.
Monoclon. Antib. Immunodiagn. Immunother. 36:272-281(2017) PubMed=32218834; DOI=10.3892/ol.2020.11384; PMCID=PMC7068343
Junko Takei, Mika Kato Kaneko, Tomokazu Ohishi, Manabu Kawada, Hiroyuki Harada, Yukinari Kato;
A novel anti-EGFR monoclonal antibody (EMab-17) exerts antitumor activity against oral squamous cell carcinomas via antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity.
Oncol. Lett. 19:2809-2816(2020) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q127382604
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| Entry history |
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| Entry creation | 30-Jan-2024 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 4 |
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