ID   LN229/EGFR
AC   CVCL_D2SN
DR   Wikidata; Q127382604
RX   PubMed=29090976;
RX   PubMed=32218834;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:6597; LIFR; Simple; p.Pro1060Ala (c.3178C>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9811; RAD21; Simple; p.Gln132Ter (c.394C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro98Leu (c.293C>T); ClinVar=VCV000528236; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With a N-terminal GVAMPGAEDDVV = PA-tag and a C-terminal with a C-terminal DMVNPGLEDRIE = RAP-tag and GDGMVPPGIEDK = MAP-tag).
CC   Derived from site: In situ; Brain, right frontal parieto-occipital cortex.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0393 ! LN-229
SX   Female
AG   60Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 19-12-24; Version: 3
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RX   PubMed=29090976; DOI=10.1089/mab.2017.0042; PMCID=PMC6975130;
RA   Itai S., Yamada S., Kaneko M.K., Chang Y.-W., Harada H., Kato Y.;
RT   "Establishment of EMab-134, a sensitive and specific anti-epidermal
RT   growth factor receptor monoclonal antibody for detecting squamous
RT   cell carcinoma cells of the oral cavity.";
RL   Monoclon. Antib. Immunodiagn. Immunother. 36:272-281(2017).
//
RX   PubMed=32218834; DOI=10.3892/ol.2020.11384; PMCID=PMC7068343;
RA   Takei J., Kaneko M.K., Ohishi T., Kawada M., Harada H., Kato Y.;
RT   "A novel anti-EGFR monoclonal antibody (EMab-17) exerts antitumor
RT   activity against oral squamous cell carcinomas via antibody-dependent
RT   cellular cytotoxicity and complement-dependent cytotoxicity.";
RL   Oncol. Lett. 19:2809-2816(2020).
//