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Cellosaurus FLC-4 (CVCL_D204)

[Text version]
Cell line name FLC-4
Synonyms FLC4; Functional Liver Cell-4
Accession CVCL_D204
Resource Identification Initiative To cite this cell line use: FLC-4 (RRID:CVCL_D204)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Japanese National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology; FERM BP-5165.
Population: Japanese.
Omics: Transcriptome analysis by microarray.
Caution: FLC-4 is often stated to be synonymous with JHH-4 (Cellosaurus=CVCL_2787), but the patent reference (Patent=US5804441) seems to indicate that FLC-4 is derived from JHH-4 and has a different karyotype.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Cys78Ter (c.234T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (from parent cell line).
Disease Hepatitis C infection (NCIt: C3098)
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2787 (JHH-4)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line

Nagamori S., Hasumura S., Kawada M., Matsuura T., Mizutani S., Yoshida H.
Human hepatoma-derived cell line FLC-4 and method for producing useful polymers by culturing the cell line.
Patent number US5804441, 08-Sep-1998

PubMed=17241388; DOI=10.1111/j.1478-3231.2006.01410.x
Kosuge M., Takizawa H., Maehashi H., Matsuura T., Matsufuji S.
A comprehensive gene expression analysis of human hepatocellular carcinoma cell lines as components of a bioartificial liver using a radial flow bioreactor.
Liver Int. 27:101-108(2007)

PubMed=21960466; DOI=10.1002/jcp.23033
Laurent T., Murase D., Tsukioka S., Matsuura T., Nagamori S., Oda H.
A novel human hepatoma cell line, FLC-4, exhibits highly enhanced liver differentiation functions through the three-dimensional cell shape.
J. Cell. Physiol. 227:2898-2906(2012)

Cell line databases/resources cancercelllines; CVCL_D204
Encyclopedic resources Wikidata; Q54834981
Polymorphism and mutation databases Cosmic; 2321031
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number11