ID   FLC-4
AC   CVCL_D204
SY   FLC4; Functional Liver Cell-4
DR   cancercelllines; CVCL_D204
DR   Cosmic; 2321031
DR   Wikidata; Q54834981
RX   Patent=US5804441;
RX   PubMed=17241388;
RX   PubMed=21960466;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Japanese National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology; FERM BP-5165.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Cys78Ter (c.234T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Caution: FLC-4 is often stated to be synonymous with JHH-4 (Cellosaurus=CVCL_2787), but the patent reference (Patent=US5804441) seems to indicate that FLC-4 is derived from JHH-4 and has a different karyotype.
DI   NCIt; C3098; Hepatitis C infection
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2787 ! JHH-4
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 05-10-23; Version: 11
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RX   Patent=US5804441;
RA   Nagamori S., Hasumura S., Kawada M., Matsuura T., Mizutani S.,
RA   Yoshida H.;
RT   "Human hepatoma-derived cell line FLC-4 and method for producing
RT   useful polymers by culturing the cell line.";
RL   Patent number US5804441, 08-Sep-1998.
//
RX   PubMed=17241388; DOI=10.1111/j.1478-3231.2006.01410.x;
RA   Kosuge M., Takizawa H., Maehashi H., Matsuura T., Matsufuji S.;
RT   "A comprehensive gene expression analysis of human hepatocellular
RT   carcinoma cell lines as components of a bioartificial liver using a
RT   radial flow bioreactor.";
RL   Liver Int. 27:101-108(2007).
//
RX   PubMed=21960466; DOI=10.1002/jcp.23033;
RA   Laurent T., Murase D., Tsukioka S., Matsuura T., Nagamori S., Oda H.;
RT   "A novel human hepatoma cell line, FLC-4, exhibits highly enhanced
RT   liver differentiation functions through the three-dimensional cell
RT   shape.";
RL   J. Cell. Physiol. 227:2898-2906(2012).
//