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Cellosaurus KT-1 [Human leukemia] (CVCL_D200)

[Text version]
Cell line name KT-1 [Human leukemia]
Synonyms KT1
Accession CVCL_D200
Resource Identification Initiative To cite this cell line use: KT-1 [Human leukemia] (RRID:CVCL_D200)
Comments Population: Japanese.
Characteristics: Sensitive to the antiproliferative and apoptosis-inducing effects of IFN-alpha.
Doubling time: 18-24 hours (PubMed=9427720).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_JH29 (KT-1/A3)CVCL_JH30 (KT-1/B7)CVCL_E9WD (KTR1)
CVCL_E9WE (KTR2)CVCL_E9WF (KTR3)CVCL_E9WG (KTR4)
CVCL_E9WH (KTR5)CVCL_E9WI (KTR6)CVCL_E9WJ (KTR7)
Sex of cell Male
Age at sampling 32Y
Category Cancer cell line
Publications

PubMed=9427720; DOI=10.1182/blood.V91.2.641
Kohsuke Yanagisawa, Hayato Yamauchi, Masahiko Kaneko, Hidehisa Kohno, Hitoshi Hasegawa, Shigeru Fujita;
Suppression of cell proliferation and the expression of a bcr-abl fusion gene and apoptotic cell death in a new human chronic myelogenous leukemia cell line, KT-1, by interferon-alpha.
Blood 91:641-648(1998)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Hans Gunther Drexler, Roderick A.F. MacLeod, Cord C. Uphoff;
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=11111114; DOI=10.1159/000041061
Hayato Yamauchi, Ikuya Sakai, Hirosi Narumi, Shinji Soga, Shigeru Fujita;
Sensitivity to interferon-alpha and interferon-stimulated gene factor 3 binding activity in human chronic myelogenous leukemia cell line KT-1.
Acta Haematol. 104:1-9(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12842705; DOI=10.1016/s0301-472x(03)00089-4
Takatsune Shimizu, Yoshitaka Miyakawa, Atsushi Oda, Masahiro Kizaki, Yasuo Ikeda;
STI571-resistant KT-1 cells are sensitive to interferon-alpha accompanied by the loss of T-cell protein tyrosine phosphatase and prolonged phosphorylation of Stat1.
Exp. Hematol. 31:601-608(2003)

PubMed=15539083; DOI=10.1016/j.exphem.2004.07.024
Takatsune Shimizu, Yoshitaka Miyakawa, Satoshi Iwata, Akiko Kuribara, Tony Tiganis, Chikao Morimoto, Yasuo Ikeda, Masahiro Kizaki;
A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein.
Exp. Hematol. 32:1057-1063(2004)

Cross-references
Encyclopedic resources Wikidata; Q54900516
Experimental variables resources EFO; EFO_0022545
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number18