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Cellosaurus HUH-7 SR (CVCL_C8ZK)

[Text version]
Cell line name HUH-7 SR
Accession CVCL_C8ZK
Resource Identification Initiative To cite this cell line use: HUH-7 SR (RRID:CVCL_C8ZK)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:50924; Sorafenib (Nexavar).
Omics: CRISPR phenotypic screen.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=31903165; DOI=10.18632/oncotarget.27361
Zheng A., Chevalier N., Calderoni M., Dubuis G., Dormond O., Ziros P.G., Sykiotis G.P., Widmann C.
CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma.
Oncotarget 10:7058-7070(2019)

CRISP screens repositories BioGRID_ORCS_Cell_line; 1535
Encyclopedic resources Wikidata; Q123032645
Entry history
Entry creation05-Oct-2023
Last entry update30-Jan-2024
Version number2