ID   HUH-7 SR
AC   CVCL_C8ZK
DR   BioGRID_ORCS_Cell_line; 1535
DR   Wikidata; Q123032645
RX   PubMed=31903165;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:50924; Sorafenib (Nexavar).
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Omics: CRISPR phenotypic screen.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
//
RX   PubMed=31903165; DOI=10.18632/oncotarget.27361;
RA   Zheng A., Chevalier N., Calderoni M., Dubuis G., Dormond O.,
RA   Ziros P.G., Sykiotis G.P., Widmann C.;
RT   "CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib,
RT   lenvatinib, and regorafenib sensitivity gene in hepatocellular
RT   carcinoma.";
RL   Oncotarget 10:7058-7070(2019).
//