Cellosaurus EndoC-betaH5 (CVCL_C7TU)
| Cell line name | EndoC-betaH5 | |
|---|---|---|
| Synonyms | EndoC-BH5 | |
| Accession | CVCL_C7TU | |
| Resource Identification Initiative | To cite this cell line use: EndoC-betaH5 (RRID:CVCL_C7TU) | |
| Comments | Characteristics: Displays robust GLP-1 and GIP receptor activity associated with insulin content and glucose stimulated insulin secretion levels, close to those of native human beta cells (Human Cell Design). Characteristics: First transduced with two vectors pTRIP DeltaU3loxP-pY-TK-RIP405-SV40LT and pTRIP DeltaU3loxP-pY-TK-RIP405-SV40-hTERT where RIP405 is a beta cell specific rat insulin promoter and pY, the polyoma virus enhancer. Was then transduced with a Lv-RIP-CreERT2, treated with tamoxifen and gancyclovir thus removing the SV40LT and hTERT immortalizing genes as well as HSV-1 TK (PubMed=37442376). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Omics: Transcriptomics; RNAseq. Derived from site: In situ; Fetal pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169. | |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | |
| Hierarchy | Children:
| |
| Sex of cell | Female | |
| Age at sampling | 8FW | |
| Category | Transformed cell line | |
| Web pages | Provider; Human Cell Design; -; https://www.humancelldesign.com/endoc-bh5/ | |
| Publications | PubMed=37442376; DOI=10.1016/j.molmet.2023.101772; PMCID=PMC10407753 | |
| Cross-references | ||
| Encyclopedic resources | Wikidata; Q117704314 | |
| Gene expression databases | GEO; GSM7029173
GEO; GSM7029174 GEO; GSM7029175 GEO; GSM7029176 GEO; GSM7029177 | |
| Entry history | ||
| Entry creation | 21-Mar-2023 | |
| Last entry update | 10-Apr-2025 | |
| Version number | 4 | |