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Cellosaurus MiaPaCa(BCRP) (CVCL_C7SQ)

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Cell line name MiaPaCa(BCRP)
Synonyms MiaPaCaBCRP
Accession CVCL_C7SQ
Resource Identification Initiative To cite this cell line use: MiaPaCa(BCRP) (RRID:CVCL_C7SQ)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_91367; Barasertib-HQPA (AZD1152-HQPA).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic undifferentiated carcinoma (NCIt: C5722)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0428 (MIA PaCa-2)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=19188929; DOI=10.1038/tpj.2008.20
Jun Guo, Mark G. Anderson, Paul Tapang, Joann P. Palma, Luis E. Rodriguez, Amanda L. Niquette, Jun-Ling Li, Jennifer J. Bouska, Gang Wang, Dimitri Semizarov, Daniel H. Albert ...Show all 14 authors... , Cherrie K. Donawho, Keith B. Glaser, O. Jameel Shah; Show fewer authors
Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152.
Pharmacogenomics J. 9:90-102(2009)

Cross-references
Encyclopedic resources Wikidata; Q117704706
Entry history
Entry creation21-Mar-2023
Last entry update10-Apr-2025
Version number4