ID   MiaPaCa(BCRP)
AC   CVCL_C7SQ
SY   MiaPaCaBCRP
DR   Wikidata; Q117704706
RX   PubMed=19188929;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_91367; Barasertib-HQPA (AZD1152-HQPA).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C5722; Pancreatic undifferentiated carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0428 ! MIA PaCa-2
SX   Male
AG   65Y
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 10-04-25; Version: 4
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RX   PubMed=19188929; DOI=10.1038/tpj.2008.20;
RA   Guo J., Anderson M.G., Tapang P., Palma J.P., Rodriguez L.E.,
RA   Niquette A.L., Li J.-L., Bouska J.J., Wang G., Semizarov D.,
RA   Albert D.H., Donawho C.K., Glaser K.B., Shah O.J.;
RT   "Identification of genes that confer tumor cell resistance to the
RT   aurora B kinase inhibitor, AZD1152.";
RL   Pharmacogenomics J. 9:90-102(2009).
//