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Cellosaurus DDT1-MF2 GR1 (CVCL_C7S1)

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Cell line name DDT1-MF2 GR1
Synonyms DDT1 MF2 GR1; GR1; DDT1 MF-2 GR
Accession CVCL_C7S1
Resource Identification Initiative To cite this cell line use: DDT1-MF2 GR1 (RRID:CVCL_C7S1)
Comments Characteristics: Glucocorticold receptor-poor variant. Growth of this cell line is completely resistant to the inhibitory action of glucocorticoids (PubMed=4058427; PubMed=8314862).
Transformant: ChEBI; CHEBI_41922; Diethylstilbestrol.
Derived from site: In situ; Vas deferens, smooth muscle; UBERON=UBERON_0004224.
Disease Hamster ductus deferens leiomyosarcoma (NCIt: C134567)
Species of origin Mesocricetus auratus (Golden hamster) (NCBI Taxonomy: 10036)
Hierarchy Parent: CVCL_3459 (DDT1-MF2)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=4058427; DOI=10.1007/BF00219391
James S. Norris, Lawrence E. Cornett, Peter O. Kohler, Stewart L. MacLeod, Allan J. Syms, Roy G. Smith;
Glucocorticoids induce a 29 000 Mr protein in DDT1 MF-2 smooth muscle cells but not in the DDT1 MF-2 GR glucocorticoid resistant variant.
Mol. Cell. Biochem. 68:79-85(1985)

PubMed=8314862; DOI=10.1002/jcp.1041560113
Wei-Min Fan, Tina M. Cooper, James S. Norris;
Characterization of selective glucocorticoid-dependent responses in a glucocorticoid-resistant smooth muscle tumor cell line.
J. Cell. Physiol. 156:88-95(1993)

Cross-references
Encyclopedic resources Wikidata; Q117704284
Entry history
Entry creation21-Mar-2023
Last entry update19-Dec-2024
Version number3