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Cellosaurus JS2 (CVCL_C7PK)

[Text version]
Cell line name JS2
Accession CVCL_C7PK
Resource Identification Initiative To cite this cell line use: JS2 (RRID:CVCL_C7PK)
Comments Knockout cell: Method=KO mouse; MGI; MGI:96824; Tlr4.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatic stellate cell; CL=CL_0000632.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_5L03 (JS2 TLR4-/- D299G)CVCL_5L05 (JS2 TLR4-/- D299G/T399I)CVCL_5L04 (JS2 TLR4-/- T399I)
CVCL_5L02 (JS2 TLR4-/- WT)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=19085953; DOI=10.1002/hep.22697; PMCID=PMC2891538
Jin-Sheng Guo, Johnny Loke, Feng Zheng, Feng Hong, Steven Yea, Masayuki Fukata, Mirko Tarocchi, Olivia Tuason Abar, Hong-Jin Huang, John J. Sninsky, Scott Laurence Friedman;
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.
Hepatology 49:960-968(2009)

PubMed=23207150; DOI=10.3760/cma.j.issn.1007-3418.2012.08.008
Zhe Zhang, Cheng-Zhao Lin, Li-Jun Peng, Yang-Yang Ouyang, Yi-Rong Cao, Jin-Sheng Guo;
HMGB1-mediated activation of TLR4 signaling in hepatic stellate cells.
Zhonghua Gan Zang Bing Za Zhi 20:581-584(2012)

Cross-references
Encyclopedic resources Wikidata; Q117704566
Entry history
Entry creation21-Mar-2023
Last entry update10-Sep-2024
Version number4