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Cellosaurus A375-NTP-R (CVCL_C7GI)

[Text version]
Cell line name A375-NTP-R
Accession CVCL_C7GI
Resource Identification Initiative To cite this cell line use: A375-NTP-R (RRID:CVCL_C7GI)
Comments Population: Caucasian.
Selected for resistance to: NCIt; C192869; Non-thermal plasma.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line

PubMed=36630862; DOI=10.1016/j.drup.2022.100914
Lin A., Sahun M., Biscop E., Verswyvel H., De Waele J., De Backer J., Theys C., Cuypers B., Laukens K., Vanden Berghe W., Smits E., Bogaerts A.
Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma.
Drug Resist. Updat. 67:100914.1-100914.16(2022)

Encyclopedic resources Wikidata; Q123030358
Entry history
Entry creation21-Mar-2023
Last entry update30-Jan-2024
Version number3