ID   A375-NTP-R
AC   CVCL_C7GI
DR   Wikidata; Q123030358
RX   PubMed=36630862;
CC   Population: Caucasian.
CC   Selected for resistance to: NCIt; C192869; Non-thermal plasma.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 30-01-24; Version: 3
//
RX   PubMed=36630862; DOI=10.1016/j.drup.2022.100914;
RA   Lin A., Sahun M., Biscop E., Verswyvel H., De Waele J., De Backer J.,
RA   Theys C., Cuypers B., Laukens K., Vanden Berghe W., Smits E.,
RA   Bogaerts A.;
RT   "Acquired non-thermal plasma resistance mediates a shift towards
RT   aerobic glycolysis and ferroptotic cell death in melanoma.";
RL   Drug Resist. Updat. 67:100914.1-100914.16(2022).
//