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Cellosaurus HepG2/CD81++ (CVCL_C5RP)

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Cell line name HepG2/CD81++
Accession CVCL_C5RP
Resource Identification Initiative To cite this cell line use: HepG2/CD81++ (RRID:CVCL_C5RP)
Comments Population: Caucasian.
Characteristics: Expresses 4 times more CD81 than HepG2-CD81 (Cellosaurus=CVCL_C5RN) (PubMed=16819966).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1701; CD81.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=16819966; DOI=10.1111/j.1462-5822.2006.00697.x
Olivier Silvie, Celine Greco, Jean-Francois Franetich, Anne Dubart-Kupperschmitt, Laurent Hannoun, Geert-Jan van Gemert, Robert W. Sauerwein, Shoshana Levy, Claude Boucheix, Eric Rubinstein, Dominique Mazier;
Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species.
Cell. Microbiol. 8:1134-1146(2006)

Cross-references
Encyclopedic resources Wikidata; Q116049313
Entry history
Entry creation15-Dec-2022
Last entry update27-Nov-2025
Version number6