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Cellosaurus HepG2-CD81 (CVCL_C5RN)

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Cell line name HepG2-CD81
Synonyms HepG2/CD81+
Accession CVCL_C5RN
Resource Identification Initiative To cite this cell line use: HepG2-CD81 (RRID:CVCL_C5RN)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1701; CD81.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=12913001; DOI=10.1074/jbc.M305289200
Birke Bartosch, Alessandra Vitelli, Christelle Granier, Caroline Goujon, Jean Dubuisson, Simona Pascale, Elisa Scarselli, Riccardo Cortese, Alfredo Nicosia, Francois-Loic Cosset;
Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.
J. Biol. Chem. 278:41624-41630(2003)

PubMed=16819966; DOI=10.1111/j.1462-5822.2006.00697.x
Olivier Silvie, Celine Greco, Jean-Francois Franetich, Anne Dubart-Kupperschmitt, Laurent Hannoun, Geert-Jan van Gemert, Robert W. Sauerwein, Shoshana Levy, Claude Boucheix, Eric Rubinstein, Dominique Mazier;
Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species.
Cell. Microbiol. 8:1134-1146(2006)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4543855
ChEMBL-Targets; CHEMBL4543887
Encyclopedic resources Wikidata; Q116049312
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number6