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Cellosaurus 5-8F (CVCL_C528)

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Cell line name 5-8F
Synonyms 58F; SUNE-1-5-8F
Accession CVCL_C528
Resource Identification Initiative To cite this cell line use: 5-8F (RRID:CVCL_C528)
Comments Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=26116706) it seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from SUNE1 which has also been shown to be contaminated.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00596.
Doubling time: 26.63 hours (PubMed=21122407).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Sequence variations
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6946 (SUNE1)
Children:
CVCL_S665 (5-8F/Erbitux)
Category Hybrid cell line
STR profile Source(s): PubMed=26116706

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,23
D3S135815,18
D5S81811,12
D6S104311,14,18
D7S82010,12
D8S117912
D12S39120,21
D13S31710,12,13.3
D16S5399,10
D18S5113,16
D19S43312,13
D21S1127,30
FGA21
Penta D9,12
Penta E17
TH017,9
TPOX8,9,12
vWA14,16

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12485491; DOI=10.3760/j.issn:0253-3766.2002.05.004
Lin-Jie Zhang, Li-Bing Song, Ying-Hong Ma, Bi-Jun Huang, Qi-Wan Liang, Yi-Xin Zeng;
Differentially expressed gene in nasopharyngeal carcinoma cell lines with various metastatic potentialities.
Zhonghua Zhong Liu Za Zhi 24:430-434(2002)

PubMed=21122407; DOI=10.3760/cma.j.issn.0253-3766.2010.08.004
Qiang Zuo, Rong-Cheng Luo;
Relationship between the insulin-like growth factor 1 receptor signaling pathway and the resistance of nasopharyngeal carcinoma to cetuximab.
Zhonghua Zhong Liu Za Zhi 32:575-579(2010)

PubMed=26116706; DOI=10.1096/fj.14-266718
Fang Ye, Chu-Guang Chen, Jian Qin, Jie Liu, Cong-Yi Zheng;
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

CLPUB00484
Zhi-Hong Xu, Wen-Wen Sun, Jun-Biao Hang, Bei-Li Gao, Jia-An Hu;
RNA-seq identified a novel functional MET fusion in head and neck cancer 5-8F cell line.
Int. J. Clin. Exp. Pathol. 9:8308-8317(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C528
Anatomy/cell type resources BTO; BTO_0006010
Encyclopedic resources Wikidata; Q54603663
Experimental variables resources EFO; EFO_0022677
Gene expression databases GEO; GSM375842
Polymorphism and mutation databases Cosmic; 1322951
Cosmic; 1459415
Progenetix; CVCL_C528
Entry history
Entry creation22-Oct-2012
Last entry update27-Nov-2025
Version number21