ID   5-8F
AC   CVCL_C528
SY   58F; SUNE-1-5-8F
DR   BTO; BTO_0006010
DR   EFO; EFO_0022677
DR   cancercelllines; CVCL_C528
DR   Cosmic; 1322951
DR   Cosmic; 1459415
DR   GEO; GSM375842
DR   Progenetix; CVCL_C528
DR   Wikidata; Q54603663
RX   CelloPub=CLPUB00484;
RX   PubMed=12485491;
RX   PubMed=21122407;
RX   PubMed=26116706;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. On the basis of the STR profile (PubMed=26116706) it seems to be a hybrid of HeLa and of cell line of unknown origin. Originally thought to originate from SUNE1 which has also been shown to be contaminated.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00596.
CC   Doubling time: 26.63 hours (PubMed=21122407).
CC   Sequence variation: Gene fusion; HGNC; HGNC:1490; CAPZA2 + HGNC; HGNC:7029; MET; Name(s)=CAPZA2-MET (CelloPub=CLPUB00484).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
ST   Source(s): PubMed=26116706
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D12S391: 20,21
ST   D13S317: 10,12,13.3
ST   D16S539: 9,10
ST   D18S51: 13,16
ST   D19S433: 12,13
ST   D21S11: 27,30
ST   D2S1338: 17,23
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D6S1043: 11,14,18
ST   D7S820: 10,12
ST   D8S1179: 12
ST   FGA: 21
ST   Penta D: 9,12
ST   Penta E: 17
ST   TH01: 7,9
ST   TPOX: 8,9,12
ST   vWA: 14,16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6946 ! SUNE1
CA   Hybrid cell line
DT   Created: 22-10-12; Last updated: 27-11-25; Version: 21
CH   CVCL_S665 ! 5-8F/Erbitux
//
RX   PubMed=12485491; DOI=10.3760/j.issn:0253-3766.2002.05.004;
RA   Zhang, Lin-Jie
RA   Song, Li-Bing
RA   Ma, Ying-Hong
RA   Huang, Bi-Jun
RA   Liang, Qi-Wan
RA   Zeng, Yi-Xin
RT   "Differentially expressed gene in nasopharyngeal carcinoma cell lines
RT   with various metastatic potentialities.";
RL   Zhonghua Zhong Liu Za Zhi 24:430-434(2002).
//
RX   PubMed=21122407; DOI=10.3760/cma.j.issn.0253-3766.2010.08.004;
RA   Zuo, Qiang
RA   Luo, Rong-Cheng
RT   "Relationship between the insulin-like growth factor 1 receptor
RT   signaling pathway and the resistance of nasopharyngeal carcinoma to
RT   cetuximab.";
RL   Zhonghua Zhong Liu Za Zhi 32:575-579(2010).
//
RX   PubMed=26116706; DOI=10.1096/fj.14-266718;
RA   Ye, Fang
RA   Chen, Chu-Guang
RA   Qin, Jian
RA   Liu, Jie
RA   Zheng, Cong-Yi
RT   "Genetic profiling reveals an alarming rate of cross-contamination
RT   among human cell lines used in China.";
RL   FASEB J. 29:4268-4272(2015).
//
RX   CelloPub=CLPUB00484;
RA   Xu, Zhi-Hong
RA   Sun, Wen-Wen
RA   Hang, Jun-Biao
RA   Gao, Bei-Li
RA   Hu, Jia-An
RT   "RNA-seq identified a novel functional MET fusion in head and neck
RT   cancer 5-8F cell line.";
RL   Int. J. Clin. Exp. Pathol. 9:8308-8317(2016).
//