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Cellosaurus A375 NY-ESO-1 Knockout (CVCL_C3D8)

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Cell line name A375 NY-ESO-1 Knockout
Synonyms A375 NY-ESO-1-/-
Accession CVCL_C3D8
Resource Identification Initiative To cite this cell line use: A375 NY-ESO-1 Knockout (RRID:CVCL_C3D8)
Comments Population: Caucasian.
Knockout cell: Method=ZFN; HGNC; HGNC:2491; CTAG1B.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Children:
CVCL_C3DA (A375 NY-ESO-1 High)CVCL_C3D9 (A375 NY-ESO-1 Low)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Sigma-Aldrich=ATG004

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,17
D5S81812
D7S8209
D8S117911,14
D13S31711,14
D16S5399
D18S5112,17
D21S1129,30
FGA23
Penta D9,15
Penta E10,12
TH018
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Cross-references
Cell line collections (Providers) Sigma-Aldrich; ATG004
Cell line databases/resources cancercelllines; CVCL_C3D8
Encyclopedic resources Wikidata; Q114310506
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number8