Cellosaurus cell line A375 NY-ESO-1 Low (CVCL

Cross-references
Cell line name	A375 NY-ESO-1 Low
Accession	CVCL_C3D9
Resource Identification Initiative	To cite this cell line use: A375 NY-ESO-1 Low (RRID:CVCL_C3D9)
Comments	Population: Caucasian. Characteristics: Expresses CTAG1B at low level (Sigma-Aldrich=ATG004). Knockout cell: Method=ZFN; HGNC; HGNC:2491; CTAG1B. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:2491; CTAG1B. Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease	Amelanotic melanoma (NCIt: C3802)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_C3D8 (A375 NY-ESO-1 Knockout)
Sex of cell	Female
Age at sampling	54Y
Category	Cancer cell line
Cell line collections (Providers)	Sigma-Aldrich; ATG004
Cell line databases/resources	cancercelllines; CVCL_C3D9
Encyclopedic resources	Wikidata; Q114310507
Entry history
Entry creation	22-Sep-2022
Last entry update	19-Dec-2024
Version number	8