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Cellosaurus J774.C3C (CVCL_C1MG)

[Text version]
Cell line name J774.C3C
Synonyms J774 clone C3C
Accession CVCL_C1MG
Resource Identification Initiative To cite this cell line use: J774.C3C (RRID:CVCL_C1MG)
Comments Characteristics: Lacks the ability to produce O2- or H2O2 when stimulated by PMA or aggregated immunoglobulin (PubMed=6252274).
Characteristics: Unable to restrict the growth of epimastigotes or trypomastigotes of Trypanosoma cruzi to a significant degree (PubMed=6350185).
Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: Macrophage; CL=CL_0000235.
Disease Mouse reticulum cell sarcoma (NCIt: C134780)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c.
Hierarchy Parent: CVCL_HA24 (J774.16)
Sex of cell Female
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=6252274; DOI=10.1084/jem.152.4.808
Damiani G., Kiyotaki C., Soeller W., Sasada M., Peisach J., Bloom B.R.
Macrophage variants in oxygen metabolism.
J. Exp. Med. 152:808-822(1980)

PubMed=7045866; DOI=10.1073/pnas.79.8.2584
Tanaka Y., Kiyotaki C., Tanowitz H., Bloom B.R.
Reconstitution of a variant macrophage cell line defective in oxygen metabolism with a H2O2-generating system.
Proc. Natl. Acad. Sci. U.S.A. 79:2584-2588(1982)

PubMed=6350185; DOI=10.1128/iai.41.3.1322-1331.1983
Tanaka Y., Tanowitz H., Bloom B.R.
Growth of Trypanosoma cruzi in a cloned macrophage cell line and in a variant defective in oxygen metabolism.
Infect. Immun. 41:1322-1331(1983)

Cross-references
Encyclopedic resources Wikidata; Q114311773
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number4