ID   J774.C3C
AC   CVCL_C1MG
SY   J774 clone C3C
DR   Wikidata; Q114311773
RX   PubMed=6252274;
RX   PubMed=6350185;
RX   PubMed=7045866;
CC   Characteristics: Lacks the ability to produce O2- or H2O2 when stimulated by PMA or aggregated immunoglobulin (PubMed=6252274).
CC   Characteristics: Unable to restrict the growth of epimastigotes or trypomastigotes of Trypanosoma cruzi to a significant degree (PubMed=6350185).
CC   Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C134780; Mouse reticulum cell sarcoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_HA24 ! J774.16
SX   Female
AG   Adult
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 4
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RX   PubMed=6252274; DOI=10.1084/jem.152.4.808;
RA   Damiani G., Kiyotaki C., Soeller W., Sasada M., Peisach J.,
RA   Bloom B.R.;
RT   "Macrophage variants in oxygen metabolism.";
RL   J. Exp. Med. 152:808-822(1980).
//
RX   PubMed=6350185; DOI=10.1128/iai.41.3.1322-1331.1983;
RA   Tanaka Y., Tanowitz H., Bloom B.R.;
RT   "Growth of Trypanosoma cruzi in a cloned macrophage cell line and in a
RT   variant defective in oxygen metabolism.";
RL   Infect. Immun. 41:1322-1331(1983).
//
RX   PubMed=7045866; DOI=10.1073/pnas.79.8.2584;
RA   Tanaka Y., Kiyotaki C., Tanowitz H., Bloom B.R.;
RT   "Reconstitution of a variant macrophage cell line defective in oxygen
RT   metabolism with a H2O2-generating system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2584-2588(1982).
//