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Cellosaurus MA09-hRPE (CVCL_C1LA)

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Cell line name MA09-hRPE
Synonyms MA09-RPE
Accession CVCL_C1LA
Resource Identification Initiative To cite this cell line use: MA09-hRPE (RRID:CVCL_C1LA)
Comments From: Astellas Institute of Regenerative Medicine (AIRM); Marlborough; USA.
Biotechnology: Used in clinical trials were it is sub-retinaly transplanted in patients with macular degeneration and Stargardt's macular dystrophy. MA09-hRPE can rescue photoreceptors and prevent loss of vision.
Characteristics: The MA09 hESC cell line was terminally differentiated into retinal pigment epithelial (RPE) cells.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C344 (MA09)
Sex of cell Female
Age at sampling Blastocyst stage
Category Finite cell line
Web pages Info; LifeMap Discovery; -; https://web.archive.org/web/20250125032248/https://discovery.lifemapsc.com/regenerative-medicine/cell-therapy-applications/eye-ma09-hrpe-human-embryonic-retinal-pigmented-epithelial-cells-for-degenerative-macular-diseases
Publications

PubMed=19521979; DOI=10.1002/stem.149
Bin Lu, Christopher Malcuit, Shao-Mei Wang, Sergej V. Girman, Peter Francis, Linda Lemieux, Robert Paul Lanza, Raymond Douglas Lund;
Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.
Stem Cells 27:2126-2135(2009)

PubMed=22281388; DOI=10.1016/S0140-6736(12)60028-2
Steven D. Schwartz, Jean-Pierre Hubschman, Gad Heilwell, Valentina Franco-Cardenas, Carolyn K. Pan, Rosaleen M. Ostrick, Edmund Mickunas, Roger Gay, Irina V. Klimanskaya, Robert Paul Lanza;
Embryonic stem cell trials for macular degeneration: a preliminary report.
Lancet 379:713-720(2012)

Patent=US10077424
Christopher Malcuit, Linda Lemieux, William Holmes, Pedro Huertas, Lucy Vilner;
Methods of producing RPE cells and compositions of RPE cells.
Patent number US10077424, 18-Sep-2018

PubMed=31482011; DOI=10.1038/s41536-019-0081-8; PMCID=PMC6712006
Tina Guan-Ting Qiu;
Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells (MA09-hRPE) in macular degeneration.
NPJ Regen. Med. 4:19.1-19.5(2019)

Cross-references
Encyclopedic resources Wikidata; Q114311911
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number5