ID   MA09-hRPE
AC   CVCL_C1LA
SY   MA09-RPE
DR   Wikidata; Q114311911
RX   Patent=US10077424;
RX   PubMed=19521979;
RX   PubMed=22281388;
RX   PubMed=31482011;
WW   Info; LifeMap Discovery; -; https://web.archive.org/web/20250125032248/https://discovery.lifemapsc.com/regenerative-medicine/cell-therapy-applications/eye-ma09-hrpe-human-embryonic-retinal-pigmented-epithelial-cells-for-degenerative-macular-diseases
CC   From: Astellas Institute of Regenerative Medicine (AIRM); Marlborough; USA.
CC   Biotechnology: Used in clinical trials were it is sub-retinaly transplanted in patients with macular degeneration and Stargardt's macular dystrophy. MA09-hRPE can rescue photoreceptors and prevent loss of vision.
CC   Characteristics: The MA09 hESC cell line was terminally differentiated into retinal pigment epithelial (RPE) cells.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C344 ! MA09
SX   Female
AG   Blastocyst stage
CA   Finite cell line
DT   Created: 22-09-22; Last updated: 10-04-25; Version: 5
//
RX   PubMed=31482011; DOI=10.1038/s41536-019-0081-8; PMCID=PMC6712006;
RA   Qiu, Tina Guan-Ting
RT   "Transplantation of human embryonic stem cell-derived retinal pigment
RT   epithelial cells (MA09-hRPE) in macular degeneration.";
RL   NPJ Regen. Med. 4:19.1-19.5(2019).
//
RX   PubMed=19521979; DOI=10.1002/stem.149;
RA   Lu, Bin
RA   Malcuit, Christopher
RA   Wang, Shao-Mei
RA   Girman, Sergej V.
RA   Francis, Peter
RA   Lemieux, Linda
RA   Lanza, Robert Paul
RA   Lund, Raymond Douglas
RT   "Long-term safety and function of RPE from human embryonic stem cells
RT   in preclinical models of macular degeneration.";
RL   Stem Cells 27:2126-2135(2009).
//
RX   PubMed=22281388; DOI=10.1016/S0140-6736(12)60028-2;
RA   Schwartz, Steven D.
RA   Hubschman, Jean-Pierre
RA   Heilwell, Gad
RA   Franco-Cardenas, Valentina
RA   Pan, Carolyn K.
RA   Ostrick, Rosaleen M.
RA   Mickunas, Edmund
RA   Gay, Roger
RA   Klimanskaya, Irina V.
RA   Lanza, Robert Paul
RT   "Embryonic stem cell trials for macular degeneration: a preliminary
RT   report.";
RL   Lancet 379:713-720(2012).
//
RX   Patent=US10077424;
RA   Malcuit, Christopher
RA   Lemieux, Linda
RA   Holmes, William
RA   Huertas, Pedro
RA   Vilner, Lucy
RT   "Methods of producing RPE cells and compositions of RPE cells.";
RL   Patent number US10077424, 18-Sep-2018.
//