ID   MA09-hRPE
AC   CVCL_C1LA
SY   MA09-RPE
DR   Wikidata; Q114311911
RX   Patent=US10077424;
RX   PubMed=19521979;
RX   PubMed=22281388;
RX   PubMed=31482011;
WW   https://discovery.lifemapsc.com/regenerative-medicine/cell-therapy-applications/eye-ma09-hrpe-human-embryonic-retinal-pigmented-epithelial-cells-for-degenerative-macular-diseases
CC   From: Astellas Institute of Regenerative Medicine (AIRM); Marlborough; USA.
CC   Biotechnology: Used in clinical trials were it is sub-retinaly transplanted in patients with macular degeneration and Stargardt's macular dystrophy. MA09-hRPE can rescue photoreceptors and prevent loss of vision.
CC   Characteristics: The MA09 hESC cell line was terminally differentiated into retinal pigment epithelial (RPE) cells.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C344 ! MA09
SX   Female
AG   Blastocyst stage
CA   Finite cell line
DT   Created: 22-09-22; Last updated: 29-06-23; Version: 4
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RX   Patent=US10077424;
RA   Malcuit C., Lemieux L., Holmes W., Huertas P., Vilner L.;
RT   "Methods of producing RPE cells and compositions of RPE cells.";
RL   Patent number US10077424, 18-Sep-2018.
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RX   PubMed=19521979; DOI=10.1002/stem.149;
RA   Lu B., Malcuit C., Wang S.-M., Girman S.V., Francis P., Lemieux L.,
RA   Lanza R.P., Lund R.D.;
RT   "Long-term safety and function of RPE from human embryonic stem cells
RT   in preclinical models of macular degeneration.";
RL   Stem Cells 27:2126-2135(2009).
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RX   PubMed=22281388; DOI=10.1016/S0140-6736(12)60028-2;
RA   Schwartz S.D., Hubschman J.-P., Heilwell G., Franco-Cardenas V.,
RA   Pan C.K., Ostrick R.M., Mickunas E., Gay R., Klimanskaya I.V.,
RA   Lanza R.P.;
RT   "Embryonic stem cell trials for macular degeneration: a preliminary
RT   report.";
RL   Lancet 379:713-720(2012).
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RX   PubMed=31482011; DOI=10.1038/s41536-019-0081-8;
RA   Qiu T.G.-T.;
RT   "Transplantation of human embryonic stem cell-derived retinal pigment
RT   epithelial cells (MA09-hRPE) in macular degeneration.";
RL   NPJ Regen. Med. 4:19-19(2019).
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