| Cell line name |
LA-N-6 MUT p53 |
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| Accession |
CVCL_C1HR |
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| Resource Identification Initiative |
To cite this cell line use: LA-N-6 MUT p53 (RRID:CVCL_C1HR) |
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| Comments |
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371. |
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| Sequence variations |
- Gene deletion; HGNC; 11998; TP53; Zygosity=Heterozygous (PubMed=28636942).
- Mutation; HGNC; 427; ALK; Simple; p.Asp1091Asn (c.3271G>A); ClinVar=VCV000218628; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro152Leu (c.455C>T); ClinVar=VCV000142766; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Tyr236Ter (c.708C>A); Zygosity=Heterozygous; Note=Acquired spontaneously at 90 PDL (PubMed=28636942).
|
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| Disease |
Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1363 (LA-N-6) |
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| Sex of cell |
Male |
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| Age at sampling |
6Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=28636942; DOI=10.1016/j.celrep.2017.05.087
Dagg R.A., Pickett H.A., Neumann A.A., Napier C.E., Henson J.D., Teber E.T., Arthur J.W., Reynolds C.P., Murray J., Haber M., Sobinoff A.P., Lau L.M.S., Reddel R.R.
Extensive proliferation of human cancer cells with ever-shorter telomeres.
Cell Rep. 19:2544-2556(2017) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_C1HR
|
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| Encyclopedic resources |
Wikidata; Q114311869
|
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| Entry history |
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| Entry creation | 22-Sep-2022 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 5 |
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