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Cellosaurus LA-N-6 (CVCL_1363)

[Text version]
Cell line name LA-N-6
Synonyms LAN-6; LAN6; LA-N-6(OAN)
Accession CVCL_1363
Resource Identification Initiative To cite this cell line use: LA-N-6 (RRID:CVCL_1363)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Characteristics: Neuroblastic type (N-type) (PubMed=15720811).
Characteristics: Has long and heterogeneous telomeres and no telomerase activity. Its telomeres shortens continuously at an average rate of 55 base pairs per population doubling (PubMed=28636942).
Doubling time: 3 days (PubMed=28636942); ~1 week (DSMZ=ACC-674).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; PTM; Tyrosine phosphorylation.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=28636942).
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Asp1091Asn (c.3271G>A); ClinVar=VCV000218628; Zygosity=Heterozygous (PubMed=18724359; Cosmic-CLP=949170; DepMap=ACH-001355).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (Cosmic-CLP=949170; DepMap=ACH-001355).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Leu (c.455C>T); ClinVar=VCV000142766; Zygosity=Heterozygous (Cosmic-CLP=949170; DepMap=ACH-001355).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.47
Native American23.6
East Asian, North3.12
East Asian, South0
South Asian0
European, North42.61
European, South28.2
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C1HR (LA-N-6 MUT p53)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): COG; Cosmic-CLP=949170; DepMap=ACH-001355; DSMZ=ACC-674

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,19
D3S135815
D5S81810,12
D7S82011,12
D8S117913,14
D13S31712
D16S53910,12
D18S5116
D19S43314
D21S1130,32.2
FGA18,21
Penta D13
Penta E7,12
TH016
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/dl/NB_Data_Sheets/LA-N-6_Cell_Line_Data_Sheet_COGcell_org.pdf
Publications

PubMed=8242562; DOI=10.1002/1097-0142(19931201)72:11<3346::AID-CNCR2820721134>3.0.CO;2-E
Randal K. Wada, Robert C. Seeger, Garrett M. Brodeur, Peggy A. Einhorn, Sylvia A. Rayner, Mary M. Tomayko, Charles Patrick Reynolds;
Human neuroblastoma cell lines that express N-myc without gene amplification.
Cancer 72:3346-3354(1993)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=11507071
Nino Keshelava, Juan J. Zuo, Ping Chen, Sitara N. Waidyaratne, Marian C. Luna, Charles Joseph Gomer, Timothy J. Triche, Charles Patrick Reynolds;
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Cancer Res. 61:6185-6193(2001)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Karl-Ludwig Schaefer, Kristin Brachwitz, Daniel H. Wai, Yvonne Braun, Raihanatou Diallo, Eberhard Korsching, Martin Eisenacher, Reinhard Voss, Frans van Valen, Claudia Baer, Barbara Selle ...Show all 18 authors... , Laura Spahn, Shuen-Kuei Liao, Kevin A.W. Lee, Pancras Cornelis Wilhelmus Hogendoorn, Guido Reifenberger, Helmut Erich Gabbert, Christopher Poremba; Show fewer authors
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=15720811; DOI=10.1593/neo.04310; PMCID=PMC1531688
Jeanette D. Walton, David R. Kattan, Sharon K. Thomas, Barbara A. Spengler, Hong-Fen Guo, June Lee Biedler, Nai-Kong V. Cheung, Robert A. Ross;
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=25884760; DOI=10.1371/journal.pcbi.1004130; PMCID=PMC4401789
Juan Palacios-Moreno, Lauren Foltz, Ai-Lan Guo, Matthew P. Stokes, Emily D. Kuehn, Lynn George, Michael J. Comb, Mark L. Grimes;
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.
PLoS Comput. Biol. 11:e1004130.1-e1004130.33(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=28636942; DOI=10.1016/j.celrep.2017.05.087
Rebecca A. Dagg, Hilda A. Pickett, Axel A. Neumann, Christine E. Napier, Jeremy David Henson, Erdahl T. Teber, Jonathan W. Arthur, Charles Patrick Reynolds, Jayne Murray, Michelle Haber, Alexander Peter Sobinoff ...Show all 13 authors... , Loretta M.S. Lau, Roger Robert Reddel; Show fewer authors
Extensive proliferation of human cancer cells with ever-shorter telomeres.
Cell Rep. 19:2544-2556(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31631027; DOI=10.1016/j.ccell.2019.09.002; PMCID=PMC6851493
Zulekha A. Qadeer, David Valle-Garcia, Dan Hasson, Zhen Sun, April Cook, Christie Nguyen, Aroa Soriano, An-Qi Ma, Lyra M. Griffiths, Maged Zeineldin, Dan Filipescu ...Show all 31 authors... , Luz Jubierre, Asif Chowdhury, Orla Deevy, Xiang Chen, David B. Finkelstein, Armita Bahrami, Elizabeth Stewart, Sara M. Federico, Soledad Gallego, Fumiko Dekio, Mary Elizabeth Fowkes, David Meni, John Matthew Maris, William Andrew Weiss, Stephen S. Roberts, Nai-Kong V. Cheung, Jian Jin, Miguel F. Segura, Michael Anthony Dyer, Emily Bernstein; Show fewer authors
ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures.
Cancer Cell 36:512-527.e9(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-674
Cell line databases/resources CLO; CLO_0037081
cancercelllines; CVCL_1363
Cell_Model_Passport; SIDM00330
Cosmic-CLP; 949170
DepMap; ACH-001355
DSMZCellDive; ACC-674
LINCS_LDP; LCL-1988
Biological sample resources BioSample; SAMN03473429
Chemistry resources ChEMBL-Cells; CHEMBL3308206
ChEMBL-Targets; CHEMBL2366123
GDSC; 949170
PharmacoDB; LAN6_819_2019
PubChem_Cell_line; CVCL_1363
Encyclopedic resources Wikidata; Q54901879
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670032
GEO; GSM2371240
GEO; GSM2394373
Polymorphism and mutation databases Cosmic; 697283
Cosmic; 717430
Cosmic; 848929
Cosmic; 930067
Cosmic; 949170
Cosmic; 1019942
Cosmic; 1109105
Cosmic; 1109366
Cosmic; 1161993
Cosmic; 1167408
Cosmic; 1526630
Cosmic; 1890102
Cosmic; 2301577
Cosmic; 2393637
IARC_TP53; 23822
IARC_TP53; 27562
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42