ID   LA-N-6 MUT p53
AC   CVCL_C1HR
DR   cancercelllines; CVCL_C1HR
DR   Wikidata; Q114311869
RX   PubMed=28636942;
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Heterozygous (PubMed=28636942).
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Asp1091Asn (c.3271G>A); ClinVar=VCV000218628; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro152Leu (c.455C>T); ClinVar=VCV000142766; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr236Ter (c.708C>A); Zygosity=Heterozygous; Note=Acquired spontaneously at 90 PDL (PubMed=28636942).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1363 ! LA-N-6
SX   Male
AG   6Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=28636942; DOI=10.1016/j.celrep.2017.05.087;
RA   Dagg R.A., Pickett H.A., Neumann A.A., Napier C.E., Henson J.D.,
RA   Teber E.T., Arthur J.W., Reynolds C.P., Murray J., Haber M.,
RA   Sobinoff A.P., Lau L.M.S., Reddel R.R.;
RT   "Extensive proliferation of human cancer cells with ever-shorter
RT   telomeres.";
RL   Cell Rep. 19:2544-2556(2017).
//