ID   LA-N-6 MUT p53
AC   CVCL_C1HR
DR   cancercelllines; CVCL_C1HR
DR   Wikidata; Q114311869
RX   PubMed=28636942;
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=28636942).
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Asp1091Asn (c.3271G>A); ClinVar=VCV000218628; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Leu (c.455C>T); ClinVar=VCV000142766; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr236Ter (c.708C>A); Zygosity=Heterozygous; Note=Acquired spontaneously at 90 PDL (PubMed=28636942).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1363 ! LA-N-6
SX   Male
AG   6Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 6
//
RX   PubMed=28636942; DOI=10.1016/j.celrep.2017.05.087;
RA   Dagg, Rebecca A.
RA   Pickett, Hilda A.
RA   Neumann, Axel A.
RA   Napier, Christine E.
RA   Henson, Jeremy David
RA   Teber, Erdahl T.
RA   Arthur, Jonathan W.
RA   Reynolds, Charles Patrick
RA   Murray, Jayne
RA   Haber, Michelle
RA   Sobinoff, Alexander Peter
RA   Lau, Loretta M.S.
RA   Reddel, Roger Robert
RT   "Extensive proliferation of human cancer cells with ever-shorter
RT   telomeres.";
RL   Cell Rep. 19:2544-2556(2017).
//