Cellosaurus logo
expasy logo

Cellosaurus 143B-GFP-HK2 (CVCL_C0Q7)

[Text version]
Cell line name 143B-GFP-HK2
Accession CVCL_C0Q7
Resource Identification Initiative To cite this cell line use: 143B-GFP-HK2 (RRID:CVCL_C0Q7)
Comments Population: Caucasian.
Characteristics: Transfected with a pCMV6-AC-HK2-GFP construct that contains HK2 c-terminally tagged with turbo-GFP (PubMed=35609998).
Transfected with: HGNC; 4923; HK2.
Transfected with: UniProtKB; Q6WV12; Pontellina plumata GFP2 (with p.Lys5Glu, p.Val117Met, p.Val149Asp, p.Val151Asp, p.Ala155Thr, p.Phe168Ser and p.Leu200Asp = TurboGFP).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2270 (143B)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line

PubMed=35609998; DOI=10.1093/nar/gkac360
Watzky M., Huard S., Juricek L., Dairou J., Chauvet C., Coumoul X., Letessier A., Miotto B.
Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling.
Nucleic Acids Res. 50:5545-5564(2022)

Cell line databases/resources cancercelllines; CVCL_C0Q7
Encyclopedic resources Wikidata; Q112926904
Entry history
Entry creation23-Jun-2022
Last entry update02-May-2024
Version number6