ID   143B-GFP-HK2
AC   CVCL_C0Q7
DR   cancercelllines; CVCL_C0Q7
DR   Wikidata; Q112926904
RX   PubMed=35609998;
CC   Population: Caucasian.
CC   Characteristics: Transfected with a pCMV6-AC-HK2-GFP construct that contains HK2 c-terminally tagged with turbo-GFP.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 4923; HK2.
CC   Transfected with: UniProtKB; Q6WV12; Pontellina plumata GFP2 (with p.Lys5Glu, p.Val117Met, p.Val149Asp, p.Val151Asp, p.Ala155Thr, p.Phe168Ser and p.Leu200Asp = TurboGFP).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2270 ! 143B
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
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RX   PubMed=35609998; DOI=10.1093/nar/gkac360;
RA   Watzky M., Huard S., Juricek L., Dairou J., Chauvet C., Coumoul X.,
RA   Letessier A., Miotto B.;
RT   "Hexokinase 2 is a transcriptional target and a positive modulator of
RT   AHR signalling.";
RL   Nucleic Acids Res. 50:5545-5564(2022).
//