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Cellosaurus AGS-PTX-R (CVCL_B7H3)

[Text version]
Cell line name AGS-PTX-R
Synonyms AGS-R
Accession CVCL_B7H3
Resource Identification Initiative To cite this cell line use: AGS-PTX-R (RRID:CVCL_B7H3)
Comments Population: Caucasian.
Doubling time: 25.6-25.8 hours (PubMed=35122114).
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: In situ; Stomach; UBERON=UBERON_0000945.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Glu (c.101G>A); ClinVar=VCV000017584; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu453Lys (c.1357G>A); ClinVar=VCV000376470; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Ala (c.1634A>C); ClinVar=VCV000013659; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Glu64del (c.192_194del); Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0139 (AGS)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=35122114; DOI=10.1007/s00210-022-02217-3
Ali Niapour, Naisana Seyedasli;
Acquisition of paclitaxel resistance modulates the biological traits of gastric cancer AGS cells and facilitates epithelial to mesenchymal transition and angiogenesis.
Naunyn Schmiedebergs Arch. Pharmacol. 395:515-533(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7H3
Encyclopedic resources Wikidata; Q112929200
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number7