ID   AGS-PTX-R
AC   CVCL_B7H3
SY   AGS-R
DR   cancercelllines; CVCL_B7H3
DR   Wikidata; Q112929200
RX   PubMed=35122114;
CC   Population: Caucasian.
CC   Doubling time: 25.6-25.8 hours (PubMed=35122114).
CC   Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly34Glu (c.101G>A); ClinVar=VCV000017584; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu453Lys (c.1357G>A); ClinVar=VCV000376470; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Ala (c.1634A>C); ClinVar=VCV000013659; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Stomach; UBERON=UBERON_0000945.
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0139 ! AGS
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=35122114; DOI=10.1007/s00210-022-02217-3;
RA   Niapour A., Seyedasli N.;
RT   "Acquisition of paclitaxel resistance modulates the biological traits
RT   of gastric cancer AGS cells and facilitates epithelial to mesenchymal
RT   transition and angiogenesis.";
RL   Naunyn Schmiedebergs Arch. Pharmacol. 395:515-533(2022).
//