Cellosaurus cell line C2BBe1 MRP2 KO (CVCL

Cell line name

C2BBe1 MRP2 KO

Synonyms

Caco-2 MRP2 Knockout Cell Line; C2BBe1 Cells MRP2 -/-/-/-

Accession

CVCL_B5ZV

To cite this cell line use: C2BBe1 MRP2 KO (RRID:CVCL_B5ZV)

Comments

Population: Caucasian.
Knockout cell: Method=ZFN; HGNC; 53; ABCC2.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.

Sequence variations

Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).

Disease

Colon adenocarcinoma (NCIt: C4349)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1096 (C2BBe1)
Children:

CVCL_B5ZW (C2BBe1 MDR1/MRP2 KO)

CVCL_B5ZX (C2BBe1 MRP2/BCRP KO)

Sex of cell

Male

Age at sampling

72Y