ID   C2BBe1 MRP2 KO
AC   CVCL_B5ZV
SY   Caco-2 MRP2 Knockout Cell Line; C2BBe1 Cells MRP2 -/-/-/-
DR   cancercelllines; CVCL_B5ZV
DR   Wikidata; Q111733041
RX   PubMed=25388687;
WW   https://www.sigmaaldrich.com/catalog/product/sigma/mtox1003
WW   https://www.sigmaaldrich.com/catalog/product/sigma/mtox1003P24
CC   Population: Caucasian.
CC   Knockout cell: Method=ZFN; HGNC; 53; ABCC2.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1096 ! C2BBe1
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 05-10-23; Version: 5
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RX   PubMed=25388687; DOI=10.1124/dmd.114.057216;
RA   Sampson K.E., Brinker A., Pratt J., Venkatraman N., Xiao Y.-L.,
RA   Blasberg J., Steiner T., Bourner M., Thompson D.C.;
RT   "Zinc finger nuclease-mediated gene knockout results in loss of
RT   transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2
RT   cells.";
RL   Drug Metab. Dispos. 43:199-207(2015).
//