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Cellosaurus C2BBe1 MDR1/MRP2 KO (CVCL_B5ZW)

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Cell line name C2BBe1 MDR1/MRP2 KO
Synonyms Caco-2 MDR1/MRP2 Double Knockout Cell Line; C2BBe1 Cells MDR1/MRP2 -/-/-/-,-/-/-/-
Accession CVCL_B5ZW
Resource Identification Initiative To cite this cell line use: C2BBe1 MDR1/MRP2 KO (RRID:CVCL_B5ZW)
Comments Population: Caucasian.
Knockout cell: Method=ZFN; HGNC; HGNC:40; ABCB1.
Knockout cell: Method=ZFN; HGNC; HGNC:53; ABCC2.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B5ZV (C2BBe1 MRP2 KO)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
Publications

PubMed=25388687; DOI=10.1124/dmd.114.057216
Kathleen E. Sampson, Amanda Brinker, Jennifer Pratt, Neetu Venkatraman, Yong-Ling Xiao, Jim Blasberg, Toni Steiner, Maureen Bourner, David C. Thompson;
Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.
Drug Metab. Dispos. 43:199-207(2015)

Cross-references
Cell line collections (Providers) Sigma-Aldrich; MTOX1005
Sigma-Aldrich; MTOX1005P24
Cell line databases/resources cancercelllines; CVCL_B5ZW
Encyclopedic resources Wikidata; Q111733038
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number7